نتایج جستجو برای: subinhibitory concentrations

تعداد نتایج: 306940  

Journal: :The Journal of antimicrobial chemotherapy 2008
Katsunori Yanagihara Yoshitomo Morinaga Shigeki Nakamura Masafumi Seki Koichi Izumikawa Hiroshi Kakeya Yoshihiro Yamamoto Yasuaki Yamada Shimeru Kamihira Shigeru Kohno

BACKGROUND Subinhibitory levels of clarithromycin and azithromycin have been shown to reduce the activity of bacterial virulence factors, but few studies have examined the effects of subinhibitory levels of telithromycin. Here, we examined the effects of telithromycin, clarithromycin and azithromycin on methicillin-resistant Staphylococcus aureus (MRSA) coagulase in vitro. We also examined the ...

Journal: :Journal of Antimicrobial Chemotherapy 1977

2015
Lee W. Goneau Thomas J. Hannan Roderick A. MacPhee Drew J. Schwartz Jean M. Macklaim Gregory B. Gloor Hassan Razvi Gregor Reid Scott J. Hultgren Jeremy P. Burton

UNLABELLED The capacity of subinhibitory levels of antibiotics to modulate bacterial virulence in vitro has recently been brought to light, raising concerns over the appropriateness of low-dose therapies, including antibiotic prophylaxis for recurrent urinary tract infection management. However, the mechanisms involved and their relevance in influencing pathogenesis have not been investigated. ...

Journal: :Journal of bacteriology 1968
M Kono K Ogawa S Mitsuhashi

Naturally occurring strains of staphylococci which are resistant to chloramphenicol (CM) inactivate this antibiotic. One of the inactivation products of CM showed the chromatographic behavior of 3-acetoxychloramphenicol. Induction of resistance occurred after prior exposure to subinhibitory concentrations of the antibiotic. The resistance of induced populations, as well as CM-inactivation abili...

Journal: :Antimicrobial agents and chemotherapy 2013
Tahsina Shireen Madhuri Singh Tiyasa Das Kasturi Mukhopadhyay

We subjected Staphylococcus aureus ATCC 29213 to serial passage in the presence of subinhibitory concentrations of magainin 2 and gramicidin D for several hundred generations. We obtained S. aureus strains with induced resistance to magainin 2 (strain 55MG) and gramicidin D (strain 55GR) that showed different phenotypic changes in membrane properties. Both exhibited a change in membrane phospho...

Journal: :Antimicrobial agents and chemotherapy 1974
C L Fox S M Modak

The role of silver and sulfadiazine in the mechanism of action of silver sulfadiazine on burn wound infections was investigated. Silver, but not sulfadiazine, was bound by bacteria. Sulfadiazine did not act as an antibacterial agent in low concentrations, but exhibited specific synergism in combination with subinhibitory levels of silver sulfadiazine. The efficacy of silver sulfadiazine is thou...

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