Gene silencing mediated by small interfering RNA (siRNA) is a novel approach in the development of new cancer therapeutics. Polycations used for nucleic acid delivery still remain heterogeneous compounds, despite continuous progress in polymer synthetic technologies. Here we report the development of a structural defined folic acid polyethylene glycol (PEG) siRNA conjugate accessible via click ...

Francesca Munari, Michal Jan Gajda, Kyoko Hiragami-Hamada, Wolfgang Fischle, Markus Zweckstetter* Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany. Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany Center f...

Elisa Biasin,1 Tim Brandt van Driel,1 Kasper S. Kjær,1, 2, 3 Asmus O. Dohn,4 Morten Christensen,1 Tobias Harlang,2 Pavel Chabera,2 Yizhu Liu,2, 5 Jens Uhlig,2 Mátyás Pápai,4, 6 Zoltán Németh,6 Robert Hartsock,3 Winnie Liang,3 Jianxin Zhang,7 Roberto Alonso-Mori,8 Matthieu Chollet,8 James M. Glownia,8 Silke Nelson,8 Dimosthenis Sokaras,8 Tadesse A. Assefa,9 Alexander Britz,9 Andreas Galler,9 Woj...

We here introduce octahedral silicon serving as a structural center for the design of hydrolytically stable bioactive complexes as demonstrated with the generation of silicon-based high affinity DNA binders. This proof-of-principle study suggests that octahedral silicon complexes are falsely neglected, promising structural templates for widespread applications in chemical biology and medicinal ...

Molecular self-assembly is central to many processes in both biology and supramolecular chemistry. The G-quartet, a hydrogen-bonded macrocycle formed by cation-templated assembly of guanosine, was first identified in 1962 as the basis for the aggregation of 5'-guanosine monophosphate. We now know that many nucleosides, oligonucleotides, and synthetic derivatives form a rich array of functional ...

Chemistry Aware Model Builder Isidro Cortes-Ciriano∗1,5, Daniel S. Murrell†2,5, Gerard J. P. van Westen, Ian P. Stott, Andreas Bender, Therese E. Malliavin, and Robert C. Glen Unite de Bioinformatique Structurale, Institut Pasteur and CNRS UMR 3825, Structural Biology and Chemistry Department, 25-28, rue Dr. Roux, 75 724 Paris, France. Unilever Centre for Molecular Science Informatics, Departme...

In contrast to the extraordinary achievements of cation complexation in host-guest chemistry, only recently has anion complexation by compounds containing electrondeficient atoms such as boron, mercury, tin and silicon received attention. We here present a new class of carborane-supported macrocyclic multidentate Lewis acid hosts which bind nucleophilic species to form isolable host-guest compl...

Structural characterization of unsupported, two metal centres bridging methyl groups is rare. They have been proposed as transmetalation intermediates in cuprate chemistry, but as yet no structural evidence has been presented. We have isolated a di-copper(i) complex with solely a methyl ligand bridging two Cu(i) atoms, representing a new bonding mode of CH3.

Reported here are the syntheses of four indazole-based ligands and the structural characterisation of four Cu(II) complexes derived from them. The ligands 1-(2-pyridyl)-1H-indazole, L1, and 2-(2-pyridyl)-2H-indazole, L2, have been characterised by single crystal X-ray diffraction methods for the first time. The intramolecular structural changes within L1 and L2 that result from the transition f...

Department for NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Am Fassberg 11, 37077 Germany Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Am Fassberg 11, 37077, Germany Biaffin GmbH & Co KG, Heinrich-Plett Strasse 40, 34132 Kassel, Germany Biomolecular Spectroscopy and Single-Molecule Detection, Max Pla...