A 52-year-old woman presented to the emergency department with gradual onset headache and expressive dysphasia. She had a left-sided facial droop and an unsteady gait on examination. An immediate non-contrast brain computed tomography (CT) was performed demonstrating evidence of prior right-sided neurosurgical intervention but no acute abnormality to account for her clinical findings (Figure 1)...

Onset of MELAS due to the m.3243ANG mutation is early if the large phenotypic variability is considered ☆ , ☆☆ Keywords: mtDNA m.3243ANG MELAS Gene Mitochondrial disorder Stroke-like episode Letter to the Editor With interest we read the article by Sunde et al. about a female with MELAS syndrome with onset at age 49 years and four stroke-like episodes (SLEs) during the first 2 years who was fol...

BACKGROUND AND PURPOSE Transcatheter closure of patent foramen ovale (PFO) has been reported to improve migraine in patients with cerebrovascular disorders in noncontrolled studies. The aim of the study was to compare the course of migraine assessed prospectively over a 12-month period in symptomatic (for cerebrovascular disease) and asymptomatic patients undergoing PFO closure and in patients ...

OBJECTIVE Previous studies on the association between migraine and the risk of developing hemorrhagic stroke (HS) have generated inconsistent results. The aim of the present population-based, age- and sex- matched follow-up study was to investigate whether migraine is associated with an increased risk of HS. METHOD A total of 20925 persons with at least two ambulatory visits in 2001 with the ...

INTRODUCTION Patent foramen ovale (PFO) is associated with the occurrence of cryptogenic strokes, transient neurological ischemic attacks (TIA) and migraine. Therefore despite the recent ambiguous results of prospective controlled trials, percutaneous closure of PFO is still performed in many centers. AIM To evaluate the safety and effectiveness of percutaneous PFO closure in the prevention o...

INTRODUCTION Patent foramen ovale (PFO) is associated with cryptogenic strokes, recurrent transient neurologic deficits, sleep apnea, decompression illness and migraines with aura. AIM We verify cryptogenic embolism recurrence after transcatheter PFO closure in patients younger than 55 years old, and determine the prevalence of migraine with aura before and after PFO closure. MATERIAL AND M...

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare genetic disorder due to NOTCH 3 mutation on chromosome 19 resulting in small vessel disease that may mimic many other neurological disorders like migraine, stroke, transient ischaemic attack (TIA), dementia psychiatric illnesses. The confirmed by testing investigations MRI skin biopsy ...

he report in this issue of JACC: Cardiovascular Intervenions from Vigna et al. (1) raises more questions about a onfusing area of medicine—the role of persistent foramen vale (PFO) closure in migraine. Persistent foramen ovale is associated with a number of iseases including migraine with aura, cryptogenic stroke, nd decompression illness (2–4). Other right-to-left shunts re also associated wit...

Recently migraine has been associated with increased arterial stiffness, procoagulant state, increased incidence of cerebral white matter lesions (WML) and stroke. Our aim was to compare the characteristics of migraineurs to headache free controls regarding their functional carotid ultrasound parameters. Sixty patients (45 women) with migraine (mean age 40.42 ± 10.61 years) were compared with 4...