A meshfree radial point interpolation method (RPIM) is developed for stress analysis of threedimensional (3D) solids, based on the Galerkin weak form formulation using 3D meshfree shape functions constructed using radial basis functions (RBFs). As the RPIM shape functions have the Kronecker delta functions property, essential boundary conditions can be enforced as easily as in the finite elemen...

A comprehensive understanding of the cellular functions of the Hsp90 molecular chaperone has remained elusive. Although Hsp90 is essential, highly abundant under normal conditions, and further induced by environmental stress, only a limited number of Hsp90 "clients" have been identified. To define Hsp90 function, a panel of genome-wide chemical-genetic screens in Saccharomyces cerevisiae were c...

introduction: neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as alzheimer’s disease, parkinson’s disease and etc. gemfibrozil is used as a therapeutic drug for hyperlipidemia. it has been shown that gemfibrozil is neuroprotecti...

Execution of fundamental cellular functions demands regulated protein folding homeostasis. Endoplasmic reticulum (ER) is an active organelle existing to implement this function by folding and modifying secretory and membrane proteins. Loss of protein folding homeostasis is central to various diseases and budding evidences suggest ER stress as being a major contributor in the development or path...

HIGHLIGHTS: Major environmental and genetic factors determining stress-related protein abundance are discussed.Major aspects of protein biological function including protein isoforms and PTMs, cellular localization and protein interactions are discussed.Functional diversity of protein isoforms and PTMs is discussed. Abiotic stresses reveal profound impacts on plant proteomes including alteratio...

Background: Endoplasmic reticulum stress (ER stress) maintains protein homeostasis in cells. Results: A novel ER stress-responsive element, ERSE-26, identified in 38 human genes, including PRNP and ERLEC1, is regulated by spliced XBP1 during ER stress. Conclusion: ER stress increases the levels of human prion protein and other proteins not previously known to be involved in the ER stress respon...

Studies of the neurobiology of suicidal behavior have become an important and integral part of psychiatric research. Over the past several years, studies of the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidality have attracted significant interest of researchers. Multiple lines of evidence including studies of levels of BDNF in blood cells and plasma of suici...

Consensus statements have concluded that there is Level 1, Grade A evidence that Pelvic Floor Muscle Treatment (PFMT) is significantly more effective thanno treatment for stress urinary incontinence (SUI) and mixed incontinence [1-3]. Reviews on PFMT in long term treatment of urinary incontinence (UI) report inconsistent results and there seems to be some doubt about the effect [1,4]. This may ...

It is widely accepted that chronic stress, which is considered a risk factor for several neuropsychiatric disorders, may have detrimental effects on prefrontal functions. In animal models, chronic stress produces morphological, physiological and functional alternations in the rat medial prefrontal cortex (mPFC). Specifically, repeated restraint stress results in mPFC dendritic atrophy that is a...