Diabetes and its complications, such as delayed wound healing, are increasing at an alarming rate in India, putting enormous strain on the country’s limited healthcare resources. Hence, present study proposes to screen/identify possible mechanisms effect of flavonoid-enriched fraction Selaginella bryopteris extract against human keratinocyte cell lines (HaCaT) streptozocin (STZ)-induced diabeti...

preliminary studies revealed that urtica dioica has been known as a plant that decrease blood glucose. despite the importance of this plant in herbal medicine, relatively little research has been down on effects of this plant on islets yet. the objective of the current study was to evaluate the effect of dried urtica dioica leaf alcoholic and aqueous extracts on the number and the diameter of t...

To study the antidiabetic activity of Chicory roots methanolic extract (MEC) in streptozotocin (STZ) induced diabetic rats. MEC of root was subjected to preliminary qualitative phytochemical investigations by using standard procedures. The extract (400 mg/kg p.o.) was screened for antidiabetic activity in STZ-induced diabetic rats (30 mg/kg, i.p.). Acute oral toxicity study for the test extract...

Diabetic nephropathy (DN) is one of the most severe complications of diabetes and remains the largest cause of end-stage renal disease in the Western world. Treatment options are limited and novel therapies that effectively slow disease progression are warranted. Previous work suggested that treatment with CTLA4-Ig (abatacept), a molecule that binds and blocks B7-1 and is licensed for the treat...