Concentrated and partially purified preparations of streptococcal supernates containing streptolysin O have been shown to inhibit selectively the oxidative metabolism of mitochondria procured from the myocardium of rabbits and guinea pigs, the findings pointing to an interference with the action of the coenzyme diphosphopyridine nucleotide (DPN) (1). Further studies have demonstrated that these...

Streptococcal sepsis in neonates is a potentially lethal condition. A wide spectrum of clinical presentations has been often reported in Group B Streptococcal infections in neonates. Bone and joint infections which are caused by Group B Streptococcus are also encountered frequently, but they have not yet been reported in case of Group A Streptococcal infection in neonates. Here, we are reportin...

OBJECTIVE To find out whether poststreptococcal reactive arthritis (PSRA) is a discrete, homogeneous clinical syndrome. METHOD Literature review from case reports and case series. RESULTS One hundred and eighty-eight cases were identified. The age distribution was bimodal, with one peak in childhood and one peak in adulthood. Eighty-three percent of streptococcal isolates were group A. The ...

The outbreak of the post-streptococcal neurological disorders related to the antibasal ganglia antibodies is broadening. In addition to the disorders such as chorea and obsessive-compulsive disorder which have been recognized previously, the movement and behavioral abnormalities are the other aspects of post-streptococcal neurological disorders.  Streptococcus is a positive-gram and coccus...

Streptococcal adhesion, invasion, intracellular trafficking, dissemination and persistence in eukaryotic cells have a variety of implications in the infection pathogenesis. While cell adhesion establishes the initial host contact, adhering bacteria exploit the host cell for their own benefit. Internalisation into the host cell is an essential step for bacterial survival and subsequent dissemina...

A number of experiments have suggested that there is an antigenic relationship between the HLA complex and streptococcal bacterial structures. Using inhibition of cytotoxicity of HLA antisera as our assay system, it was demonstrated that the inhibitory effect on HLA cytotoxicity by streptococcal antigens is, in reality, due to activation and consumption of components of the alternate complement...

Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with streptococcal M protein and cardiac myosin. Recent studies have unraveled the potent...

collagen, which is widely distributed in pluricellular animals, is one of the most fundamental constituents of the extracellular matrix, and plays mechanically or physiologically important roles in their bodies. in this study, the biochemical and physical characteristics of pepsin-solubilized collagen from the mantle of yesso scallop (ympc), a by-product of processing, was determined. electroph...

objective(s): epidermolysis bullosa is one of the most important series of mechano-bullous heritable skin disorders which is categorized into four major types according to the layer that bullae forms within basement membrane zone. in dystrophic form of the disease, blisters are made in the sublamina densa zone, at the level of type vii collagen protein which produce anchoring fibrils. type vii ...