Introduction and purpose of the work:Proton pump inhibitors are used to reduce gastric acidity by irreversibly inhibiting hydrogen-potassium ATPase present in parietal cells stomach. These drugs more often, often not accordance with recommendations. There reports suggesting a relationship between chronic PPI use occurrence cancer. The aim study is information on proton risk developing cancer.St...

New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer,...

We conducted a comparative case-control analysis of stomach cancer and atrophie gastritis involving 427 cases with stomach cancer, 1414 cases with atrophie gastritis, and 3014 control subjects based on a questionnaire survey conducted for the subjects who received gastroscopie examination at Aichi Cancer Center Hospital from April 1985 to March 1989. The risk of atrophie gastritis in both males...

BACKGROUND In vitro, in vivo and clinical studies have demonstrated anti-cancer effects of deuterium depleted water (DDW). The nature of this agents action, cytotoxic or cytostatic, remains to be elucidated. We here aimed to address the point by examining effects on different cell lines. MATERIALS AND METHODS 3-(4, 5-dimethylthiazol- 2-yl)-2, 5-diphenyltetrazolium bromide (MTT) -based cytotox...

background: depression and anxiety had negative effects on the quality of life of cancer patients, thus hospital anxiety and depression scale (hads) is a useful instrument for screening these problems. this research was performed to assess the prevalence of their anxiety and depression. methods: from 2012-2013, one hundred fifty patients with recent diagnosis of different cancers in babol, iran...

background: adipose derived stem cells (ascs) provoke the accumulation and expansion of regulatory t cells, leading to the modulation of immune responses in tumor microenvironment. objective: to assess the effect of tumoral ascs on the trend of regulatory t cells differentiation. methods: peripheral blood naïve cd4+ t cells were co-cultured with ascs derived from breast cancer or normal breast ...