Stereotactic Radiosurgery (SRS) is a technology that utilizes externally generated ionizing radiation to treat (a) defined target(s) in the head or spine without the need to make an incision. The target is defined by high-resolution stereotactic imaging. It uses multiple convergent beams aimed to the target. The beams deliver a maximal dose to the target (with precision of less than 1mm), while...

Neovascular age-related macular degeneration is a leading cause of blindness in the developed world. Currently, the treatment of choice is intravitreal injections of anti-VEGF medications. These require frequent dosing, up to monthly, and impose a substantial burden on patients and the health economy. Ionizing radiation was proposed as a possible treatment for age-related macular degeneration d...

Stereotactic radiosurgery (SRS) provides excellent control in the treatment of brain metastases (BM). The use of newer, targeted and immunotherapy treatments have resulted in improved overall survival in patients even with an extensive metastatic disease. Hence, it is increasingly important to consider the potential for late toxicities like radiation-induced necrosis (RN) of the brain. We prese...

An emerging strength of stereotactic RFTC is its high precision brain areas where conventional resection would carry a nificant risk for persistent neurological deficits. This observation s been made before by other groups who applied stereotactic TC to hypothalamic hamartomas and periventricular nodular terotopia. The volume-of-destruction achieved by RFTC can be anticipated liably. Commercial...

BACKGROUND Stereotactic radiosurgery is widely applied to deliver additional dose to head and neck tumors. However, its safety and efficacy remains equivocal. METHODS One hundred eighty-four patients with primary head and neck cancers treated between January 1990 and August 2012 with Gamma Knife stereotactic radiosurgery were retrospectively reviewed. RESULTS Two hundred fifteen sites were ...

The best treatment approach for solitary brain metastasis is not well defined and there is no consensus on this issue. It is still being debated whether patients with isolated brain metastasis should undergo surgical resection or stereotactic radiosurgery, and which patients should receive adjuvant whole brain radiotherapy. The median survival in patients with single or multiple metastatic lesi...

Endoscope biopsy guided navigation for intra-parenchymal lesions is safe and effective, but determination of the entry point and trajectory of the endoscopic biopsy is less clear. We describe preoperative planning based on stereotactic methods, and achieving the plan using several techniques. The preoperative planning was based on stereotactic methods such as determining target, entry point, an...

During the past 20 years, stereotactic radiosurgery in the form of a multisource cobalt-60 gamma knife has been used to treat more than 1500 selected cases of intracranial arteriovenous malformations (AVMs) worldwide (1-5). Precise three-dimensional localization of the target volume is required for computer planning and radiation dose determination (6). Although either computed tomography (CT) ...

Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. We present here a Raman spectroscopic tool for detecting microcalcifications in breast tissue based on their chemical composition. We collected ex vivo Raman spectra from 159 tissue sites in fresh stereotactic breast needle biopsies from 33 patients, including 54 normal sites,...

BACKGROUND Intracranial delivery of high-dose radiation treatment with stereotactic techniques has paved the way for treatment of extracranial sites. METHODS The authors review the evolution of stereotactic body radiation therapy (SBRT) and its application to tumors in the lung and abdomen, addressing both the technical concerns associated with treatment delivery and the emerging clinical dat...