Epilepsy is a highly debilitating disorder by unpredictable seizures associated with emotional disturbance. One potential treatment for seizure and depression is dietary therapy. So, this study evaluated effects of daily oral administration of sesame and flaxseed oils in depression and seizure. Twenty-one adult male mice were divided into the following groups: control (normal saline recipient, ...

Background and Objective: Lipolysaccharide (LPS) is a large molecule isolated from bacteria such as the enterobacteriaceae family with a negative effect on memory and learning through disturbing the balance of free radicals and creating oxidative stress conditions. In this study, we evaluated  the effect of quercetin on oxidative stress and LPS-induced memory impairment in the rat. Materials a...

Both aging and age-associated neurodegenerative diseases are related with various degrees of behavioral impairments, and among the prime candidates responsible for producing the neuronal changes mediating these behavioral deficits, appear to be free radicals and the oxidative agents which they generate. Free radicals such as vit. E may be important factors in maintaining neuronal integrity and ...

Both aging and age-associated neurodegenerative diseases are related with various degrees of behavioral impairments, and among the prime candidates responsible for producing the neuronal changes mediating these behavioral deficits, appear to be free radicals and the oxidative agents which they generate. Free radicals such as vit. E may be important factors in maintaining neuronal integrity and ...

Introduction: Sub-chronic swim stress is known to induce a prolonged hyperalgesia, which is mediated through NMDA and opioid systems. Nitric oxide is a soluble gas, which acts as a retrograde messenger that modulates the release of mentioned neurotransmitters. It is also involved in nociception and memory. The aim of this study was to evaluate the role of NO pathway in nociception and memory...

These experiments examined the effects of pre-test intra dorsal hippocampus (intra-CA1) administration of GABAA receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. Male NMRI mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received IP injections of either saline (10 mL/kg...