When stimulated with a constant stimulus, many neurons initially respond with a high spike frequency that then decays down to a lower steady-state frequency (Fig. 1 A). This dynamics of the spike frequency response is referred to as “spike-frequency adaptation”. Spike-frequency adaptation is a process that is slower than the dynamics of action potential generation. Spikefrequency adaptation by ...

We investigate the behavior of a system composed of two small identical water droplets loaded with an activator-inhibitor system possessing only a single stable steady state and coupled through a third, ‘‘signaling’’ species able to diffuse through the interdroplet medium. Depending on whether the third species is coupled to the activator or the inhibitor, the system can exhibit wave instabilit...