Short interfering RNAs trigger histone silencing marks and stalling of RNA polymerase II at their genomic target sites through a mechanism termed transcriptional gene silencing (TGS). The Argonaute protein NRDE-3, along with NRDE-2, are needed for TGS in C. elegans. TGS also inhibits elongation and controls alternative splicing in mammalian cells.

One of the new features introdu Speed Downlink Packet Access (H protocol enhancements designed throughput to users with favorabl the N-channel stop-and-wait (SAW paper, we investigate the perform presence of the stalling of packe reordering buffer due to the N impacts of different transmission and mobile speed are also investiga

Video streaming currently dominates global Internet traffic and will be of even increasing importance in the future. In this paper we assess the impact of the underlying transport protocol on the user perceived quality for video streaming using YouTube as example. In particular, we investigate whether UDP or TCP fits better for Video-on-Demand delivery from the end user’s perspective, when the ...

Epstein-Barr virus (EBV) immortalizes resting B-cells and is a key etiologic agent in the development of numerous cancers. The essential EBV-encoded protein EBNA 2 activates the viral C promoter (Cp) producing a message of ~120 kb that is differentially spliced to encode all EBNAs required for immortalization. We have previously shown that EBNA 2-activated transcription is dependent on the acti...

Intracellular transport is an essential function in eucaryotic cells, facilitated by motor proteins-proteins converting chemical energy into kinetic energy. It is understood that motor proteins work in teams enabling unidirectional and bidirectional transport of intracellular cargo over long distances. Disruptions of the underlying transport mechanisms, often caused by mutations that alter sing...

Intracellular transport is an essential function in eucaryotic cells, facilitated by motor proteins proteins converting chemical energy into kinetic energy. It is understood that motor proteins work in teams enabling unidirectional and bidirectional transport of intracellular cargo over long distances. Disruptions of the underlying transport mechanisms, often caused by mutations that alter sing...