Somatostatin (SST) is a neuropeptide involved in several central processes. In hippocampus, SST hyperpolarizes CA1 pyramidal neurons and augments the K+ M current (IM). However, the limited involvement of IM at resting potential in these cells suggests that the peptide also may modulate another channel to hyperpolarize hippocampal pyramidal neurons (HPNs). We studied the effect of SST on nonina...

The Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) with the capability of measuring sea surface temperature (SST) in the presence of clouds, has been providing an unprecedented view of tropical basin-scale SST variability. In this paper, an assessment of the accuracy of the SST derived from TMI over the Bay of Bengal using in situ data collected from moored buoys and research...

A La Niña took place in the equatorial Pacific in 1999, and strong tropical instability waves (TIWs) developed, causing large meanders of a sea surface temperature (SST) front between the equator and 3◦N. High-resolution satellite measurements are used to describe the variability of SST, surface wind velocity, column-integrated water vapor, cloud liquid water and precipitation associated with t...

The newly developed multireceptor somatostatin analogs pasireotide (SOM230), octreotide and somatoprim (DG3173) have primarily been characterized according to their binding profiles. However, their ability to activate individual somatostatin receptor subtypes (sst) has not been directly assessed so far. Here, we transplanted the carboxyl-terminal phosphorylation motif of the sst(2) receptor to ...

OBJECTIVES Secretin stimulation testing (SST) is used to evaluate patients with hypergastrinemia in the diagnosis of Zollinger-Ellison syndrome. Case series have documented false-positive SST in patients with achlorhydria. This study reviews our experience with SST in hypochlorhydric and achlorhydric patients. METHODS We examined 27 patients with hypochlorhydria or achlorhydria based on a pre...

Cushing’s disease is Cushing’s syndrome caused by an adrenocorticotropic hormone-secreting pituitary adenoma and, in the absence of adequate treatment, can be fatal. Cushing’s disease represents an unmet medical need, with no approved medical therapies. Pasireotide is a novel multi-receptor-targeted somatostatin analogue with high affinity for sst 1,2,3 and sst 5 . Compared with octreotide, pas...

The dominant pattern of tropical and subtropical North Atlantic sea surface temperature (SST) anomalies simulated in the GFDL coupled ocean-atmosphere model is identified and compared to observations. The spatial pattern and temporal variability of that pattern resemble observational results. On interannual time scales it is shown that anomalous surface heat fluxes, consistent with variations i...

Short term forecasts of meteorological parameters (including precipitation) over the oceans is often difficult because of the lack of observations used to initialize the forecast models in these regions. While sea surface temperature (SST) fields derived from satellite and in situ data currently provided to the models provide some large scale information on surface forcing, the small scale grad...