spermatogonial stem cell (ssc) technologies provide multiple opportunities for research in the field of biotechnology and regenerative medicine. the therapeutic use of embryonic stem cells (escs) is restricted due to severe ethical and immunological concerns. therefore, we need a new pluripotent cell type. despite well-known role of germ cells in the gametogenesis, some facts apparently show th...

Background Male infertility management has made significant progress during the past three decades, especially after the introduction of intracytoplasmic sperm injection (ICSI) in 1992. However, many boys and men still suffer from primary testicular failure due to acquired or genetic causes. New and novel treatments are needed to address these issues. Spermatogenesis originates from spermatogon...

objective: this study presents an efficient, cost-effective method to improve proliferation and colonization of spermatogonial stem cells (sscs) in vitro. methods: isolated sscs from neonate mice were cultured in dmem culture medium with 10% fetal bovine serum (fbs). in the first phase of the study, the temperature was controlled by low intensity pulsed ultrasound stimulation (lipus) of the pla...

BACKGROUND We report the clinical presentation, radiographic studies, intraoperative findings, histopathological analysis, and post-treatment outcome in 26 patients diagnosed with spinal synovial cysts (SSCs). AIMS To describe the clinical presentation, radiographic studies, operative findings, and postoperative follow-up in 26 patients with SSCs. SETTINGS AND DESIGN The study was retrospec...

Objective We found seminal B7-H3 was associated with human sperm concentration. However, the mechanism is unclear. The purpose of this study was to investigate the expression of B7-H3 in mouse testis and determine the effects of B7-H3 on the proliferation of mouse spermatogonial stem cells (SSCs) and the underlying mechanisms. Methods B7-H3 expression in the testis of mice at different ages (...

Abstract The center of the nearby galaxy NGC 253 hosts a population more than dozen super star clusters (SSCs) that are still in process forming. majority formation burst is concentrated these SSCs, and starburst powering multiphase outflow from galaxy. In this work, we measure 350 GHz dust continuum emission toward at 47 mas (0.8 pc) resolution using data Atacama Large Millimeter/submillimeter...

Here, we aimed to answer important and fundamental questions in germ cell biology with special focus on the age of the male donor cells and the possibility to generate embryonic stem cell- (ESC-) like cells. While it is believed that spermatogonial stem cells (SSCs) and truly pluripotent ESC-like cells can be isolated from adult mice, it remained unknown if the spontaneous conversion of SSCs to...