Automating a software process both magnifies its strengths and accentuates its weaknesses. Automation can make an effective process more effective, but it can make a chaotic process even worse—and at considerable expense. Anyone who buys expensive tools to solve an ill-defined problem is likely to be disappointed. Unless procuring such tools is part of a thoughtful software process improvement ...

Our study of the Seti River in far western Nepal shows that the solute chemistry of the river and its tributaries is strongly controlled by geology. The Seti flows through four distinct terranes, starting with the Tethyan sedimentary series (TSS) and Greater Himalayan series (GHS). TSS/GHS waters display Sr/Sr ratios of ,0.73 and high Sr and Ca, consistent with the composition of limestone and ...

PURPOSE The present review article aims to provide an overview of the available radionuclides for palliative treatment of bone metastases beyond (89)Sr and (153)Sm. In addition, it aims to review and summarize the clinical outcomes associated with the palliative treatment of bone metastases using different radiopharmaceuticals. MATERIALS AND METHODS A literature search was conducted on Scienc...

Hepatitis C virus (HCV) enters cells via a pH- and clathrin-dependent endocytic pathway. Scavenger receptor BI (SR-BI) and CD81 are important entry factors for HCV internalization into target cells. The SR-BI gene gives rise to at least two mRNA splice variants, SR-BI and SR-BII, which differ in their C termini. SR-BI internalization remains poorly understood, but SR-BII is reported to endocyto...

Cardiac alternans are thought to be a precursor to life-threatening arrhythmias. Previous studies suggested that alterations in sarcoplasmic reticulum (SR) Ca2+ content are either causative or not associated with myocyte Ca2+ alternans. However, those studies used indirect measures of SR Ca2+. Here we used direct continuous measurement of intra-SR free [Ca2+] ([Ca2+]SR) (using Fluo5N) during fr...

(87)Sr/(86)Sr reference maps (isoscapes) are a key tool for investigating past human and animal migrations. However, there is little understanding of which biosphere samples are best proxies for local bioavailable Sr when dealing with movements of past populations. In this study, biological and geological samples (ground vegetation, tree leaves, rock leachates, water, soil extracts, as well as ...