I this issue, Arbyn et al (see p. 167) update the evidence about the accuracy of liquid-based cytology compared with conventional cytology, and the results are not encouraging.1 In summary, best evidence suggests that liquid-based cytology does not lead to more disease detection and appears to increase false-positive testing, sobering news given that over 80% of U.S. obstetrician–gynecologists ...

The interaction of tissue-cultured cells derived from normal squamous epithelium, normal connective tissue, and intraepithelial neoplasia of the adult human uterine cervix was studied using phase-contrast time-lapse cinematography. The fibroblasts exhibited typical, passive, contact inhibition to other fibroblasts but not to the normal epithelial cells or cells from intraepithelial neoplasia. T...

BACKGROUND The category atypical glandular cells of undetermined significance (AGUS) occurs in about 0.5% of Papanicolaou smears. Although recent case series report a great many dysplastic, cancerous, and precancerous lesions of the cervix and endometrium associated with AGUS, little attention has been focused on this issue in primary care literature. METHODS We report a case series of 52 wom...

AIMS To evaluate cytokeratin (CK) 7/20 expression patterns in salivary gland neoplasia. METHODS AND RESULTS Formalin-fixed paraffin embedded tissue from 153 salivary gland tumours were evaluated for CK7/20 immunoreactivity. The tumours included pleomorphic adenoma (n = 24), myoepithelioma (n = 9), papillary cystadenoma (n = 3), oncocytoma (n = 2), adenoid cystic carcinoma (n = 22), mucoepider...

Heat shock protein (HSP) is thought to play important roles in the cell cycle and various process of carcinogenesis. This study was performed to evaluate the expression of heat shock protein (HSP70) and estrogen receptor (ER) and Ki-67 and to assess relationship between them in cervical squamous cell neoplasia. The materials were 50 cervical squamous cell lesions, consisted of 30 cervical intra...

OBJECTIVE Glycogen synthase kinase 3β (GSK3β) is a pluripotent protein kinase involved in the development of cancers through regulation of numerous oncogenic molecules. Cyclin D1, an important regulator of G1 to S phase transition in various cells, is one of target proteins that GSK3β regulate. Our objective was to assess the expression of GSK3β and cyclin D1 in cervical neoplasm of different h...

Role of the protein overexpression is very important in the pathogenesis, diagnosis and prognosis of neoplasia. Cases of overexpression of p53 and Ki67 proteins were investigated in 19 ocular squamous cell carcinomas (OSCC) in dairy cows. Microscopically, insix cases the tumors were carcinoma in situ (noninvasive carcinoma, G0), and in the remaining 13 cases the tumors were invasive carcinoma. ...

Results HPV-HR (high-risk) was positive in 377 cases, HPV-LR (low-risk) was positive in 165 cases and in 35 cases no HPV typing was performed. The herpes virus type 2 infection was present in 2 cases. Cytology showed LSIL (low grade squamous intraepithelial lesion) in 329 cases and HSIL (high grade squamous intraepithelial lesion) in 189 cases. Histological examination revealed cervical intraep...

Cervical squamous cell carcinoma is the second most common cancer in women worldwide (zur Hausen et al., 2002). In recent years, this disease has increased gradually in China; therefore, it is very important to establish early detection of high-grade cervical intraepithelial neoplasia (CIN), which is the precursor of invasive cervical squamous cell carcinoma. It is a major challenge in screenin...

The aim of the present study was to determine the value of human papillomavirus (HPV) testing in screening patients with preinvasive cervical lesions. Seven hundred thirty-four women diagnosed with atypical squamous cells of undetermined significance (ASCUS+) cervical cytology during routine screening had additional cytologic testing and HPV DNA testing within 6 months of their diagnosis, after...