Epidermal growth factor receptor (EGFR) overexpression is observed in a number of malignancies, especially those of esophageal squamous cell origin. However, little is known about the biological functions of EGFR in primary esophageal squamous epithelial cells. Using newly established primary human esophageal squamous epithelial cells as a platform, we overexpressed EGFR through retroviral tran...

Note: An invasive epithelial neoplasm with varying degrees of squamous differentiation that arises from the following anatomic sites: the oral cavity, particularly oral soft tissues including the gingival and alveolar mucosa, floor of the mouth, tongue, soft and hard palates, tonsils and oropharynx. Oral squamous cell carcinomas (SCC) have a propensity to early and extensive lymph node metastases.

The aim of this quality controlling study was to determine the accuracy of liquid-based cytology (LBC) with the Turbitec cytocentrifuge technique. Cervical smears of 632 women, who were referred to our CIN outpatient department, after at least two smears with ASCUS or higher were evaluated and compared with the histological outcome. In 592 cases the smears revealed abnormalities of squamous epi...

The trigeminal nerve gives rise to the corneal subbasal system, which plays a crucial role in sensations of touch, pain, and temperature ocular healing processes. Technological advancements instruments, particular vivo confocal microscopy aethesiometry, have allowed for structural functional evaluation nerves health disease. Through application these technologies humans animal models, abnormali...

Authors' conclusions 1. Estimates of test sensitivity and test specificity for the new devices could not be reliably determined. The research reviewed here provides no evidence for improved detection of high-grade abnormalities by new devices for cervical screening. New devices should demonstrate clinical effectiveness gains in detecting higher grade abnormalities. Highgrade squamous intraepith...

Human squamous epithelial cells produce lower amounts of laminin and fibronectin when cultured on DEAE-dextran than when cultured on gelatin-coated polystyrene (Biotechnol. Bioeng., 33:1235). The epithelial cells also spread much more slowly on DEAE-dextran than they do on gelatin-coated polystyrene. To determine if the low level of matrix production by cells grown on DEAE-dextran contributed t...

Feagins LA, Zhang HY, Zhang X, Hormi-Carver K, Thomas T, Terada LS, Spechler SJ, Souza RF. Mechanisms of oxidant production in esophageal squamous cell and Barrett’s cell lines. Am J Physiol Gastrointest Liver Physiol 294: G411–G417, 2008. First published December 6, 2007; doi:10.1152/ajpgi.00373.2007.—We hypothesized that differences among individuals in reflux-induced oxidant production by es...

Oral squamous papilloma is a benign epithelial tumor that constitutes around 2.5% of all oral verruco-papillary lesions and caused by the Human Papilloma Virus (HPV). HPV subtypes 6 11, which are considered to be low carcinogenic potential usually associated with papilloma. Though there no site predilection as such, most common intraoral sites reported tongue, lips, buccal mucosa, gingiva, pala...

OBJECTIVE To estimate the prevalence and pattern of conjuctival squamous cell carcinoma (CSCC) in patients with HIV infection. DESIGN A hospital based cross sectional study. SETTING Kenyatta National Hospital (KNH) and Kikuyu Eye Unit (KEU) during the period November 2003 and May 2004. SUBJECTS Four hundred and nine HIV positive patients. RESULTS Four hundred and nine HIV positive patie...