Base-unpairing regions (BURs) contain a specialized DNA context with an exceptionally high unwinding propensity, and are typically identified within various matrix attachment regions. A BUR affinity column was used to purify a doublet of Mr 20,000 proteins from human breast carcinoma cells. These proteins were identified as the high-mobility group (HMG) protein, HMG-I, and its splicing variant,...

Numerous researches demonstrated the possibility of derivation of Schwann-like (SC-like) cells in vitro from bone marrow stromal cells (BMSCs). However, the concentration of the induce factors were different in those studies, especially for the critical factors forskolin (FSK) and β-heregulin (HRG). Here, we used a new and useful method to build an integrated microfluidic chip for rapid analyse...

Intravenous (IV) iron is the mainstay of treatment for deficiency anemia (IDA), when oral cannot be used or there a need rapid delivery. Ferric carboxymaltose (FCM) widely IV preparation known to cause moderate/severe hypophosphatemia (serum phosphate <0.65mmol/L; <2mg/dL) in up 75% patients. This study aimed analyze length hospital stay (LoS) and related cost inpatients with no/mild versus pos...

Although human epidermal growth factor receptor 2 (HER2) overexpression is implicated in tumor progression for a variety of cancer types, how it dysregulates signaling networks governing cell behavioral functions is poorly understood. To address this problem, we use quantitative mass spectrometry to analyze dynamic effects of HER2 overexpression on phosphotyrosine signaling in human mammary epi...

The hadron resonance gas (HRG) model is often believed to correctly describe the confined phase of QCD. This assumption basis many phenomenological works on QCD thermodynamics and analysis yields in relativistic heavy ion collisions. We use first principle lattice simulations calculate corrections ideal HRG model. Namely, we determine subleading fugacity expansion coefficients grand canonical f...

Integration of biomarkers into the majority of drug development programs has led to a need for robust measurements and assay validation techniques for analyses of biological samples. The importance of solid methodologies for biomarker assessment is heightened by the fact that new drugs frequently only offer modest benefit and that many potential biomarkers are continuous variables, the applicat...

We study the chiral condensate for 2 + 1 flavor QCD with physical quarks within a non-interacting Hadron Resonance Gas (HRG) model. By including latest information on mass variation of hadrons concerning light quark mass, from lattice and perturbation theory, we show that it is possible to quite accurately account crossover transition even conventional HRG have calculated pseudocritical tempera...

Histidine-rich glycoprotein (HRGP) is a human plasma and platelet protein of apparently diverse biological functions. In this study a new interaction for HRGP is described. HRGP specifically interacts with fibrinogen as demonstrated by two independent systems. Using an enzyme-linked immunosorbent assay it was demonstrated that HRGP bound to adsorbed fibrinogen in a concentration-dependent and s...