Background: One of the mutated genes associated with a lower level of 5MTHF necessary for DNA methylation and possibly implicated in the carcinogenesis of sporadic colorectal cancer (CRC) is the gene encoding the methylenetetrahydrofolate reductase enzyme (MTHFR). Objectives: to investigate the frequency of the C667T and A1298C MTHFR variants in patients with sporadic CRC and controls; to estab...

OBJECTIVE To investigate the molecular etiologic causes of sporadic nonsyndromic hearing loss in Chinese children. METHODS 179 sporadic nonsyndromic hearing loss children were subjected to microarray-based mutation detection for nine hot spot mutations in four of the most common deafness-related genes, including GJB2, SLC26A4, GJB3, and 12s rRNA. RESULTS The incidence of positive genetic er...

Recent studies suggest that Cu/Zn superoxide dismutase (SOD1) could be pathogenic in both familial and sporadic amyotrophic lateral sclerosis (ALS) through either inheritable or nonheritable modifications. The presence of a misfolded WT SOD1 in patients with sporadic ALS, along with the recently reported evidence that reducing SOD1 levels in astrocytes derived from sporadic patients inhibits as...

Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two forms of PD in terms of brain abnormalities using resting-state functional MRI and graph theory. Thirty-one familial PD patients and 36 sporad...

Kuru provides our principal experience of an epidemic human prion disease and primarily affected the Fore linguistic group of the Eastern Highlands of Papua New Guinea. Kuru was transmitted by the practice of consuming dead relatives as a mark of respect and mourning (transumption). To date, detailed information of the prion strain type propagated in kuru has been lacking. Here, we directly com...

We study the homotopy relation between the standard 2-local geometry ∆ and the Bouc complex for the sporadic group Co3. We also give a result concerning the relative projectivity of the reduced Lefschetz module L̃(∆).

This paper completes the construction of the Brauer tree of the sporadic simple Thompson group in characteristic 19. Our main computational tool to arrive at this result is a new parallel implementation of the DirectCondense method.

We give an algorithm for enumerating cosets of a group defined as a finite homomorphic image of a semi-direct product of free products of cyclic groups by a group of monomial automorphisms. Lots of finite groups, including some of the sporadic simple groups can be defined in this mannar. Mathematics Subject Classification: 20Bxx

In this paper, we study the probability that a randomly chosen element in a finite group has a square root, in particular the simple groups of Lie type of rank 1, the sporadic finite simple groups and the alternating groups.