An article in the National Post on suicidal effects associated with varenicline (Champix) highlights deficiencies in the Canadian spontaneous reporting system (SRS) for adverse drug reactions (ADRs). The issues of under-reporting, poor quality information, duplication of reports and lack of a population denominator of drug use are discussed. Canada's SRS is deficient. There are immediate and me...

background: neuroectodermal tumors (pnet) are malignant small cells neoplasm mainly occurring in children but can occur at any age. extensive bleeding into the pleural cavity is rare in children. hemothorax would be compatible with a variety of congenital anomalies including sequestration, patent ductus artreiosus, and pulmonary arteriovenous malformation. case report: a 2.5-years old girl who ...

Healthcare organizations are focusing on the identification and management of Adverse drug reactions (ADRs) because of their linkages with medical problems, patient outcomes and drug discovery. The acquisition and processing of ADR-related information is challenged by the inefficiency of spontaneous reporting systems, the difficulty of promoting self-reporting by patients and the use of social ...

OBJECTIVE To analyze the association between pioglitazone use and bladder cancer through a spontaneous adverse event reporting system for medications. RESEARCH DESIGN AND METHODS Case/noncase bladder cancer reports associated with antidiabetic drug use were retrieved from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) between 2004 and 2009 and analyzed by th...

Renal cell carcinoma (RCC) comprises 3-4% of all malignant tumours among adults in Poland. Spontaneous regression of RCC is a rare but well-known phenomenon. Its frequency is estimated to be approximately 1% and a large part of the percentage is accounted for by the regression of pulmonary metastases in the course of clear type of RCC treatment. We searched PubMed, Embase and SciVerse Scopus da...

Acute abdomen during pregnancy is not an uncommon emergency in obstetrical practice. But dilemma occurs when no cause is found despite thorough workup and investigations, even on laparotomy. Peritonitis though may occur during pregnancy following tubal rupture in ectopic pregnancy or other intra abdominal conditions but spontaneous bacterial peritonitis is rarest of rare occurrence during pregn...

BACKGROUND Spontaneous adverse drug reaction reporting is the most widely used and cost effective method of monitoring the safety of drugs. This method is heavily afflicted by underreporting by healthcare professionals. The study aims at assessing adverse drug reaction (ADR) reporting rate by doctors, knowledge of the reporting system and attitudes to SADR in the Greater Accra region. METHODS...