ondary lysosomes. It is unknown exactly how the impaired lysosomal function results in the clinical features, but it is likely that retained storage material in the retina along with other, yet-to-be– elucidated mechanisms results in widespread RPE dysfunction and photoreceptor death. In conclusion, the 2 patients presented herein and those described by Springer et al demonstrate that, in addit...

We herein report the cases of 3 patients with thymic epithelial tumours, including two thymomas and a carcinoma, where the tumours spontaneously regressed in size. The patients were all female ranging in age from 32 to 43 years. During 1 or 2 months without any treatment, the tumours regressed by 25-59% in size. The pleural effusion observed in 2 patients also disappeared during the same period...

BACKGROUND The aim of this report is to present a case of spontaneous regression of traumatic lumbar epidural hematomas. CASE REPORT A 45-year-old man presented at our clinic after falling from a height. After admission, anterior compression was detected by X-ray, so lumbar spinal CT was performed. For ligament damage, emergency MR was performed. There was acute hematoma at 1 cm diameter, whi...

Congenital self-healing reticulohistiocytosis is a rare, benign, self-limiting variant of Langerhans cell histiocytosis (LCH). LCH encompasses a group of idiopathic disorders characterized by the clonal proliferation of Langerhans cells. Congenital self-healing reticulohistiocytosis typically appears at birth or in the neonatal period as isolated cutaneous lesions, often appearing as multiple c...

Spontaneous regression of metastatic melanoma is a rare event with only 76 cases having been reported since 1866. The precise mechanism of regression remains unknown. We present a case of a man with spontaneous regression of pulmonary metastatic melanoma confirmed on histopathology accompanied by reduction in fluorodeoxyglucose-activity on serial positron emission tomography/computed tomography...

INDIAN PEDIATRICS 1253 VOLUME 42DECEMBER 17, 2005 A 9-year-old boy, previously healthy, was referred to our center with 10 days of fever, weakness, epistaxis and purpura. Examination revealed a febrile child who had marked pallor; petechiae over limbs and trunk; 1-1.5 cm multiple sub-mental lymph nodes; 3 cm hepatomegaly and 5 cm splenomegaly below costal margins respectively. Investigations (T...

Merkel cell carcinoma is a rare aggressive neuroendocrine carcinoma of the skin predominantly affecting elderly Caucasians. It has a high rate of local recurrence and regional lymph node metastases. It is associated with a poor prognosis. Complete spontaneous regression of Merkel cell carcinoma has been reported but is a poorly understood phenomenon. Here we present a case of complete spontaneo...

A 72-year-old woman with advanced ascending colon cancer and an intraductal papillary mucinous neoplasm (IPMN) of the pancreatic head was treated by right hemicolectomy (RHC) and pylorus-preserving pancreaticoduodenectomy (PpPD). Adjuvant chemotherapy was not administered. Multimodal examinations at 5 months after surgery detected a solitary metastatic liver tumor derived from cancer of the asc...