Background: Psoriasis is an autoimmune-mediated disease characterized marked by thickened plaques and erythematous skin, which can be treated topical delivery of apremilast. The objective this study was to prepare hydrogel-based nanoemulsions apremilast for psoriasis therapy with a view improving its solubility permeability. Methods: Nanoemulsion components were chosen based on their solubility...

To reduce the surface and interfacial tension of the pollutants in environment, biosurfactants which are produced by the microorganisms such as bacteria, yeast etc. are being applied in large quantity. These compounds are produced extracellularly by the microorganism into the environment and they are applied in different industries such as detergent, cosmetics etc. for different purposes. In th...

Proteins are mostly used to stabilize food emulsions; however, production of protein containing emulsions is notoriously difficult to capture in scaling relations due to the complex behavior of proteins in interfaces, in combination with the dynamic nature of the emulsification process. Here, we investigate premix membrane emulsification and use the Ohnesorge number to derive a scaling relation...

Aqueous microdroplets provide miniaturized reaction compartments for numerous chemical, biochemical or pharmaceutical applications. We introduce centrifugal step emulsification for the fast and easy production of monodisperse droplets. Homogenous droplets with pre-selectable diameters in a range from 120 μm to 170 μm were generated with coefficients of variation of 2-4% and zero run-in time or ...

This work addresses the model-based optimization of the operation procedure of an emulsification process using a stirred vessel in combination with a colloid mill and a recycle. The computation of input trajectories (i.e. the stirrer and rotor speed in time), for reaching a certain predefined drop size distribution in minimal time, is studied. It is argued that gradient based optimization techn...

Novel biosurfactant-producing strains were isolated from hydrocarboncontaminated environments that exclusively utilize agro-waste as their primary carbon source for the expression of biosurfactants. These were quantified using various standardized methods. Among the agro-waste screened, Beta vulgaris (Beetroot) proved to be the most suitable substrate, for which the biosurfactants produced by t...

Thistle oil (INCI: Silybum marianum seed oil) is known as an anti-oxidant, moisturizing and skin regenerating cosmetic raw material. Nanoemulsions are a new form of cosmetic product showing very good user properties (ease of spreading over the skin with no greasy feeling). Moreover, due to their structure, they can also transport both hydrophilic and hydrophobic active substances to the skin. T...

Atorvastatin is a BCS class II lipid lowering agent. It is insoluble in aqueous solution of pH 4 and below; it is very slightly soluble in water and pH 7.4 phosphate buffer. In the present investigation an attempt has been made to enhance solubility and dissolution of poorly soluble drug by formulating self microemulsifying drug delivery system (SMEDDS). The solubility of atorvastatin in indivi...

The present work was aimed to develop and characterize rosuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia (RSEDDS) for improving bioavailability, to enhance solubility, to prolong residence time and to provide sufficient amount of drug to a target site in a sustained release manner. Self-emulsifying drug delivery system was prepared by simple...

The microstructure of the water rich microemulsion phase of the Cj~E~. water and decane system has been studied using surfactant ~H-NMR relaxation and 'H Fourier transform pulsed gradient spin-echo jFTPGSE) self-diffusion experiments. The surfactant-to-oil ratio is kept