We tested the hypothesis that phosphodiesterase type 5 inhibitor (PDE5i) use would be associated with increased likelihood of condom breakage using an event-specific analysis. A convenience sample of 440 men completed an internet-based questionnaire that assessed variables pertaining to the last time they used condoms for penile-vaginal intercourse (PVI). A bivariate (screening) analysis was pe...

Tetrahymena telomeres are protected by a protein complex composed of Pot1, Tpt1, Pat1, and Pat2. Pot1 binds the 3' overhang and serves multiple roles in telomere maintenance. Here we describe Pot2, a paralog of Pot1 which has evolved a novel function during Tetrahymena sexual reproduction. Pot2 is unnecessary for telomere maintenance during vegetative growth, as the telomere structure is unaffe...

Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under conditions that partially inhibit DNA replication, and often coincide with genes deleted, amplified, or rearranged in cancer. While a substantial ...

In this work, we introduce mechanistic considerations in nonlinear milling of particulate material. We show that the mobility of the powder can have a significant effect on the breakage frequency. During grinding, the change in particle size leads to changes in the mobility of the powder which in turn alters the breakage rate. The mechanistic modeling, being able to accommodate different respon...

In the cold rolling mill, coil breakage that generated in rolling process makes the various types of troubles such as the degradation of productivity and the damage of equipment. Recent researches were done by the mechanical analysis such as the analysis of roll chattering or strip inclining and the prevention of breakage that detects the crack of coil. But they could cover some kind of breakag...

Human lymphocyte cultures were examined for chromosome damage after exposure to ultrasound. Control and treated slides were scored "blind" and showed no evidence of damage due to ultrasound. Neither was there evidence of chromosome damage in blood cultures from six infants whose mothers had ultrasound during pregnancy when compared with that from six infants whose mothers had not. Our results s...

Particle breakage in soils is a well-recognised behaviour. Conventional methods for quantifying the process rely on calculating area between particle size distribution (PSD) curves produced before and after crushing. A key aspect of understanding across different size/sieve fractions. Grading entropy coordinates allow representation any PSD to be shown as single point Cartesian plane are able t...

Dicentric chromosomes undergo a breakage-fusion-bridge cycle as a consequence of having two centromeres on the same chromatid attach to opposite spindle poles in mitosis. Suppression of dicentric chromosome breakage reflects loss of kinetochore function at the kinetochore-microtubule or the kinetochore-DNA interface. Using a conditionally functional dicentric chromosome in vivo, we demonstrate ...

fracture mapping of late permian-early triassic flat-lying sedimentary rocks in the sydney basin,new south wales, australia, shows that joints developed originally in extension were faulted in subsequentevents. joints with a regional distribution fall into two (early and late) formed groups. group i joints propagatedhorizontally and never interfered with each other. these joints were subsequent...