Dendritic cells (DC) are known to develop from macrophage dendritic progenitors (MDP) in bone marrow (BM), which give rise to conventional (c)DC and monocytes, both dominant antigen presenting cell (APC) subsets in spleen. This laboratory has however defined a distinct dendritic-like cell subset in spleen (L-DC), which can also be derived in long-term cultures of spleen. In line with the restri...

The teleost spleen is a discrete organ containing, in addition to erythrocytes sequestered from the circulation, erythropoietic tissue involved in the synthesis of new erythrocytes. In this division into supply and synthesis, there appear to be some species differences. The eel spleen is an erythrocyte reservoir but is not thought to be a major erythropoietic organ (Johansson-Sjobeck, 1979). Th...

To clarify the morphological characteristics of the cynomolgus monkey immune system, we analyzed quantitative data on their lymphoid organs. Spleens, major lymph nodes and Peyer's patches were sampled from cynomolgus monkeys, and the lymphoid follicle and germinal center areas and percentages of CD3- and CD20-positive areas were calculated. All the organs analyzed showed large interindividual v...

A 49 year old man with previous history of colectomy for colon cancer was referred to our department for further evaluation of suspicious hepatic lesions noticed during an abdominal CT scan. 99mTc-RBC scan revealed multiple hot spots in the region of the liver, correlating to the CT and liver-spleen scan. Further follow-ups of the patient revealed no remarkable change in the size or numbe...

wandering spleen is an uncommon entity in adults and has been described only rarely with sigmoid volvulus, that rarely affects children and adolescents. it is usually described in adults.wandering spleen characterized by the abnormal location of the spleen, caused by incomplete fusion of the four primary splenic ligaments, allowing the spleen to be mobile within the abdomen.the wandering spleen...

We studied the effects of protein-energy malnutrition on the liver morphology of rats as compared to animal emaciation and to reduction in size of the organs not irrigated by splanchnic blood such as kidneys and spleen. The animals were divided into two groups, one of them fed ad libitum rate (N = 10) and the other (N = 14) receiving water but no food for 7 days, and the changes in animal weigh...

Delahunty R, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220775 Description A 77-year-old Caucasian man presented to the oncology service with de novo v-raf murine sarcoma viral oncogene homolog B (BRAF), wild-type metastatic melanoma and widespread disease involving; subcutaneous fat, lymph nodes, bone and spleen with no history of autoimmunity. At diagnosis, the spleen was measured within ...

conclusions the association of horseshoe kidney with a wandering spleen in this case may be due to an embryological anomaly. introduction a wandering spleen occurs when there is a laxity of the ligaments that fix the spleen in its normal anatomical position. case presentation this is a case report of a wandering spleen with horseshoe kidney in a 29-year-old male admitted with acute lower abdomi...

although splenic metastasis is fairly common in disseminated cancer, solitary splenic metastasis in the absence of diffuse dissemination is rare. we report a case of 44 year-old man who developed isolated splenic metastasis of colon cancer. the patient had undergone right sided hemicolectomy for colon cancer in 1988. in 2001, he underwent reoperation because of local recurrence of tumor in the ...

Signal regulatory protein α (SIRPα), is an immunoglobulin superfamily protein that is predominantly expressed in macrophages and dendritic cells (DCs), especially CD4+ conventional DCs (cDCs). In this study, we demonstrated that, in addition to the reduced number of CD4+ cDCs, the number of T cells was significantly decreased in the spleen of Sirpa-/- mice, in which full-length of SIRPα protein...