The efficacy of diuretics in the management of rosiglitazone (RSG)-induced fluid retention was evaluated in a multicenter, randomized, open-label, parallel-group, proof-of-concept study. Of 381 patients who had type 2 diabetes and were on treatment with sulfonylurea or sulfonylurea plus metformin, 260 (63% male, 37% female) showed evidence of volume expansion as defined by an absolute reduction...

Cross-linked sulfonated polyacrylamide (Cross-PAA-SO3H) attached to nano-Fe3O4 as an efficientheterogeneous solid acid catalyst has been used for the preparation of spiro[pyrazoloquinoline-oxindoles]and spiro[chromenopyrazolo-oxindoles] through a four-component reactions of phenylhydrazineor hydrazine hydrate, isatins, ketoesters and naphthylamine or 2-naphthol under reflux co...

X-ray crystallography unequivocally shows that protection of the free hydroxyl group of 3,5-O-benzyl-idene-d-xylono-1,4-lactone with diphenyl-diazo-methane proceeded smoothly to give the title compound, C(25)H(22)O(5), with no accompanying epimerization. Unlike the analogously protected lyxono lactone, the isomeric xylono lactone has two mol-ecules present in the asymmetric unit (Z' = 2). The 5...

The reactivity of quinoneimines towards ketene and diphenylketene was examined. N-Phenylbenzoquinoneirnines (I), (2) and also N-phenylnaphthoquinoneimine react with ketene to give the spiro-adducts (5), (7) and (1 1) respectively. These adducts were stable even after prolonged heating in high boiling solvent. Reaction of the above imines with diphenylketene also afforded 13- lactam spiro-a...

Cyril Poriel introduces the Journal of Materials Chemistry C Editor's choice web collection on advances in ‘Spiro compounds for electronics’.

ABSTRACT. One-pot, mild and efficient synthesis of various spiro-nitrogen heterocycle compounds, based on the reaction ninhydrin 1,2-diamino-benzene, (indenoquinoxalin), with N-heterocycle compounds dialkylacetylenedicarboxylates is described. Using this approach, at a temperature 50-60 °C in acetonitrile solvent, can be obtained very high yields.
 
 KEY WORDS: Ninhydrin, 1,2-Diaminob...

It is my sad editorial duty to acknowledge that Professor David Hadden, previous editor of this Journal died earlier this year. As a previous editor he has his obituary published here and I thank Professor Patrick Bell for rising to this sad task so diligently. David bore his final illness with great dignity, clearly determined that while he was alive, he would live (dum vivimus, vivamus). The ...

• NHCs catalyzes polymerization of lactones by acting as a base. Electronic effects determines the activation energy. Electron withdrawing groups on decreases catalytic activity. Highly basic may change reaction mechanism. HOMO energy correlates with eneregy. Polymerization reactions using renewable raw material substrate (namely, ?-valerolactone) and N-heterocyclic carbenes (NHC) organocatalys...

The present study examined the interaction of four 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (atorvastatin, lovastatin, and simvastatin in acid and lactone forms, and pravastatin in acid form only) with multidrug resistance gene 1 (MDR1, ABCB1) P-glycoprotein, multidrug resistance-associated protein 2 (MRP2, ABCC2), and organic anion-transporting polypeptide 1B1 (OATP1B1, SLCO2...

The Rhodococcus erythropolis strain W2 has been shown previously to degrade the N-acylhomoserine lactone (AHL) quorum-sensing signal molecule N-hexanoyl-L-homoserine lactone, produced by other bacteria. Data presented here indicate that this Gram-positive bacterium is also capable of using various AHLs as the sole carbon and energy source. The enzymic activities responsible for AHL inactivation...