Dear Dr. Bedrossian: Although histological examination is by-and-far considered the gold standard for most soft tissue diagnoses, fine needle aspiration (FNA) is an excellent modality to determine the initial characteristics of the lesion in question. To our knowledge, there have been only two reported cases of ordinary lipoma and spindle-cell lipoma occurring at the same time in the same patie...

BACKGROUND Vascular endothelial cell excessive proliferation is the main biological behavior of hemangioma. Rapamycin regulates the growth of endothelial cells by inhibiting mammalian target of rapamycin (mTOR). Thus hemangioma accompanied by excessive mTOR activation should be sensitive to rapamycin. We aimed to illustrate the effect of low-concentration rapamycin on hemangioma and provide a s...

Epithelioid haemangioendothelioma (EHE) is a rare tumour of endothelial cell origin that arises from soft tissue, liver, lungs and rarely, the brain. We present a case of cerebral EHE in a 43 year old previously well female, who suffered two generalised tonic-clonic seizures. Contrast enhanced CT and MRI brain showed a left frontal lobe vividly enhancing intra-axial lesion at the grey-white jun...

Vulvar epithelioid hemangioendothelioma as primary site is extremely rare tumor that may be confused with other mesenchymal tumors due to their rarity and its histologic features. We report a case of 46-year-old woman who presented to hospital with left vulvar mass. The mass was located in subcutaneous area of vulva, and well marginated contrast enhanced on radiologic examination. Local excisio...

Background. Hepatic epithelioid hemangioendothelioma is a rare malignant tumor of vascular origin with frequent multifocal appearance. Liver resection may cause tumor spread. Liver transplantation has been indicated for unresectable nodules. We hypothesized that adjuvant interferon treatment is effective to prevent metastasis after liver resection. We report a case of multifocal hepatic epithel...

In asymmetric divisions, the mitotic spindle must align according to the cell polarity axis. This is achieved through targeting astral microtubules emanating from each spindle pole to opposite cell cortex compartments. Saccharomyces cerevisiae is a powerful genetic model for dissection of this complex process. Intense research in this yeast has rendered detailed models for a program linking act...

Primary malignant vascular bone tumors are unusual and include hemangioendothelioma, epitheloid hemangioendothelioma and angiosarcoma. Although few cases of primary bone angiosarcomas have been reported, those of femoral origin are even more infrequent. Such tumors diagnosis may be challenging due to their radiographic and histologic variety. We present a case of a 24-yearold woman with a subpe...

BACKGROUND Hemangioendothelioma includes several types of vascular neoplasms , as well as both benign and malignant growth. CASE PRESENTATION This study evaluated a case of a 78-year-old female diagnosed with composite hemangioendothelioma (CHE). This patient had an 18-month history of painless inflammatory lesions and erythema on the left forehead and right upper eyelid. The clinical and pat...

leiomyoma is a very rare intraocular tumor, which can occur in the iris, ciliary body and choroids. we report a case of choroidal leiomyoma in a 16-years old women whose left eye was enucleated because of clinical suspicion for melanoma. using conventional light microscopy tumor was interpreted as spindle cell tumor, most probably of neurogenic origin and after using immunohistochemical studies...