Introduction Spinal vascular system is the conduit through which nutrition, cells and drugs access the parenchyma of the spinal cord (SC). This system is severely damaged as a principal consequence of the spinal cord injury (SCI). The initial vascular damage plays a critical role in establishing the course of the well-established postinjury cascade including compromised blood spinal cord permea...

Recent results have shown that exercise training promotes the recovery of injured rat distal spinal cords, but are still unclear about the function of skeletal muscle in this process. Herein, rats with incomplete thoracic (T10) spinal cord injuries (SCI) with a dual spinal lesion model were subjected to four weeks of treadmill training and then were treated with complete spinal transection at T...

Curing spinal cord injury (SCI) in mammals is a daunting task because of the lack of permissive mechanisms and strong inhibitory responses at and around the lesion. The neural cell adhesion molecule L1CAM (L1) has been shown to favor axonal regrowth and enhance neuronal survival and synaptic plasticity but delivery of full-length L1 or its extracellular domain could encounter difficulties in tr...

Pain is a significant problem in diseases affecting the spinal cord, including demyelinating disease. To date, studies have examined the reliability of clinical measures for assessing and classifying the severity of spinal cord injury (SCI) and also to evaluate SCI-related pain. Most of this research has focused on adult populations and patients with traumatic injuries. Little research exists r...

The most common injury in rugby resulting in spinal cord injury (SCI) is cervical facet dislocation. We report on the outcome of a series of 57 patients with acute SCI and facet dislocation sustained when playing rugby and treated by reduction between 1988 and 2000 in Conradie Hospital, Cape Town. A total of 32 patients were completely paralysed at the time of reduction. Of these 32, eight were...

121 ABSTRACT According to the World Health Organization, disability is defined as a restriction of bodily structure or function that is not offset by social measures, with spinal cord injuries (SCI) being a common type of physical disability. Several factors may influence the nutritional status of individuals with SCI, and metabolic complications can lead to a number of acute and chronic change...

To the Editor: Spinal cord injuries (SCIs) are frequently reported in earthquakes.1-3 Pakistan is among 9 countries that account for more than 80% of earthquake-related injuries.4 An earthquake on October 8, 2005, in Kashmir, Pakistan, left more than 73,000 persons dead. This earthquake resulted in an estimated 650 to 750 SCIs.5 Management of SCI victims offered challenges such as saturation of...

central nervous system axons fail to regenerate after spinal cord injury (sci), partially due to the accumulation of extracellular matrix molecules in the lesion and formation of the glial scar. depakine, as known as histone deacetylase inhibitor, has neuroprotective effects. this study evaluated the histological changes (cavitation and axon regeneration) after sci associated with (following ad...

Every year, millions of people around the world suffer spinal cord injuries, traumatic brain injuries, and strokes. Spinal cord injury (SCI) often strikes young and healthy individuals and is estimated to affect between 11.5 and 57.8 individuals per million around the world, causing death, paralysis, and serious secondary medical complications [1]. Costs associated with SCI have been estimated ...

BACKGROUND Spinal cord injury (SCI) is a devastating condition with limited therapeutic options despite decades of research. Current treatment options include use of steroids, surgery, and rehabilitation. Nevertheless, many patients with SCI remain disabled. MLC601 (NeuroAiD), a combination of natural products, has been shown to be safe and to aid neurological recovery after brain injuries and ...