background: the availability of testis specific genes will be of help in choosing the most promising biomarkers for the detection of testicular sperm retrieval in patients with non-obstructive azoospermia (noa). testis specific chromodomain protein y 1 (cdy1) is a histone acetyltransferase which concentrates in the round spermatid nucleus, where histone hyperacetylation occurs and causes the re...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Infertility is a health problem that touches around 15% of couples worldwide and male infertility is the sole cause in half of these cases (1,2). Since the development of assisted reproductive techniques (ART) particularly intracytoplasmic sperm injection (ICSI), it has been a challenge to select the very best spermat...

During spermatogenesis, sperm chromatin undergoes structural changes and results in a high condensation. This nuclear compaction would be useful as a predictor of sperm fertilization capacity and pregnancy outcome. We purpose to evaluate firstly the relationship among chromatin maturity assessed by aniline blue staining (AB) and the semen parameters in infertile men. Secondly, we analyzed wheth...

Oxidative stress is detrimental to sperm function and a significant factor in the etiology of male infertility. This report examines the association between dietary and supplementary intake of the antioxidants vitamin C, vitamin E, and beta-carotene and sperm chromatin integrity. Eighty-seven healthy male volunteers donated semen samples, completed food-frequency questionnaires, and provided in...

Abnormalities in the male genome are a clear potential reason for post fertilization failure. Male infertility may arise due to high levels of loosely packaged chromatin and damaged DNA. The achievement of a correct chromatin packaging level is essential for successful fertilization. The chromatin contained in the nuclei of mammalian spermatozoa is an extremely compact and stable structure. The...

BACKGROUND Research has suggested an association with ambient air pollution and sperm quality. OBJECTIVES We investigated the effect of exposure to ozone (O3) and particulate matter < 2.5 microm in aerodynamic diameter (PM2.5) on sperm quality. METHODS We reexamined a previous cohort study of water disinfection by-products to evaluate sperm quality in 228 presumed fertile men with different...

Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a highly compact and complex structure and is capable of decondensation-features that must be present in order for a spermatozoon to be considered fertile. Any form of sperm chromatin abnormalities or DNA damage may result in male infertility. In support of this conclusion, it was reported that in-vivo...

Background: Little is known about Giberellic acid, a plant growth regulator used in many countries, on sperm parameters; so this study was conducted to evaluate its effects on sperm parameters. Materials and Methods: A number of twenty seven adult rats were divided into three groups (n=9): control group (C), control-sham group (C-Sh) and treatment group (Tr). The C-Shgroupand the Tr group were ...

The nature of subfertility due to the male or inseminate is as complex as that of the female. Fertilization failure or failure in embryogenesis are both documented to be of seminal origin. Males also differ in the numbers of sperm required to reach their maximum fertilization rate. Males requiring more sperm would be considered to have compensable seminal deficiencies. These include a number of...