hydatid cyst fluid has been used as a source of antigen for the serodiagnosis of echinococcus granulosus infection. due to cross-reactions with antigens shared by other helminthes, the specific antigen from hydatid cyst fluid was purified by many workers. we used a relatively simple technique for purification of specific antigen from sheep hydatid cyst fluid. isopycnic ultracentrifugation with ...

We have studied the components of a complex of tumor-specific antigens to determine if all of the components of the complex were lost during progression from a rather benign regressor tumor to a highly malignant (HM) cancer. We find that the HM tumor cells have lost antigens recognized by CTL but retained antigens recognized by Th cells. Immunization with variants expressing Th-defined antigens...

Knowledge of clinically targetable tumor antigens is becoming vital for broader design and utility therapeutic cancer vaccines. This information obtained reliably by directly interrogating the MHC-I presented peptide ligands, immunopeptidome, with state-of-the-art mass spectrometry. Our manuscript describes direct identification novel an aggressive triple-negative breast model. Immunopeptidome ...

The seroreactivities of both naturally and experimentally infected cats to Bartonella henselae was examined. Serum samples collected weekly from nine cats experimentally infected with B. henselae LSU16 were tested by enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. The magnitude and isotype of the antibody response were investigated by ELISA. Western blot analysis allowed th...

BACKGROUND: Toxocara canis is the most prevalent intestinal roundworm of canid species. OBJECTIVES: This study aims to evaluate the effects of Toxocara canis excretory-secretory antigens (TcES Ag) on modulating the immune system in Experimental Allergic Encephalomyelitis (EAE) model. METHODS: Adult worms of T.canis were collected from dogs to obtain excretory-secretory antigens. Female C57BL/6m...

A molecular characterization of cross-reactive antigens of Treponema pallidum Nichols and Treponema phagedenis biotype Reiter that are reactive with normal and syphilitic human sera is described. At least 8 common polypeptides, 14 T. pallidum-specific antigens, and 2 T. phagedenis biotype Reiter-specific antigens were identified.

Burnet envisaged the early presence of self-antigens in development, or ‘the history’ an animal, ablates animal's ability to immunologically respond against them. Lederberg added idea that continuous is required maintain tolerance throughout life. We refer Lederberg's proposal as ‘The Historical Postulate’. The mechanism central tolerance, now understood, consistent with Postulate. Some observa...

Autoimmune encephalitis is a difficult clinical diagnosis due to the similarities in the clini­cal, imaging and laboratory findings of many forms of autoimmune and infectious encephalitis. Autoimmune encephalitis involves several types: The first group includes the classic paraneo­plastic disorders associated with antibodies to intracellular antigens. The second group involves autoanti...