BACKGROUND Rigorous studies are necessary to demonstrate suitability of metabolomics platforms to profile metabolites in archived plasma within epidemiologic studies of human disease, for which attenuation of effect estimates due to measurement error is a key concern. METHODS Using a liquid chromatography-tandem mass spectrometry platform, we quantified 257 metabolites from archived plasma to...

HYPOTHESIS Our predictive scoring system, Estimation of Physiologic Ability and Surgical Stress, can estimate surgical costs. DESIGN Multicenter cohort study for 1 year. SETTING Six national hospitals in Japan. PATIENTS A consecutive series of 929 patients who underwent elective gastrointestinal operations. MAIN OUTCOME MEASURES The preoperative and the comprehensive risk scores of the ...

AIM To investigate the relationship between glucose metabolism and glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC). METHODS Immunohistochemical staining of pathological samples for GPC3 and glucose transporter 1 (GLUT1), and whole-body 18F-FDG PET/CT for measuring tumour glucose uptake were performed in 55 newly diagnosed HCC patients. The maximum standard uptake value (SUVmax)...

background : zoonotic cutaneous leishmaniasis (zcl), an important public health problem in iran, is sensitive to climate conditions. this study aimed to examine dynamic relations between the climate factors and incidence of zcl in golestan province, northern iran during 2010–2012. methods : data of monthly climatic factors, including temperature variables, relative humidity variables, evaporati...

Spearman distance is a permutation distance which might prove useful for coding, e.g. for codes on permutations. It turns out, however, that the Spearman geometry of strings is rather unruly from the point of view of error correction and error detection, and special care has to be taken to discriminate between the two notions of codeword distance and codeword distinguishability. All of this str...

Four thyroid function indices were determined in the sera of 181 patients: total thyroxine (T-4), the triiodothyronine resin uptake (T-3 B.C.-index), the free thyroxine (T-4) index, and the effective thyroxine ratio (E.T.R.).A statistically significant correlation between the free T-4 index and E.T.R. could be established though this correlation seemed to be worse than could be expected from th...