Enhanced reticulospinal output in patients with (REEP1) hereditary spastic paraplegia type 31. Always use the definitive version when citing. The striking paradox of pure autosomal dominant hereditary spastic paraplegia (AD HSP), in contrast to capsular stroke or primary lateral sclerosis, for example, is that despite extensive corticospinal tract (CST) degeneration and prominent lower limb spa...

Even though robotic rehabilitation is very useful to improve motor function, there is no conclusive evidence on its role in reducing post-stroke spasticity. Focal muscle vibration (MV) is instead very useful to reduce segmental spasticity, with a consequent positive effect on motor function. Therefore, it could be possible to strengthen the effects of robotic rehabilitation by coupling MV. To t...

Spastic paraplegia, optic atrophy, and neuropathy (SPOAN) is an autosomal recessive complicated form of hereditary spastic paraplegia, which is clinically defined by congenital optic atrophy, infancy-onset progressive spastic paraplegia and peripheral neuropathy. In this study, which included 61 individuals (age 5-72 years, 42 females) affected by SPOAN, a comprehensive motor and functional eva...

Evaluation of the Effect Kinesio Taping on Plantar Arch Index Children with Spastic Diplegic Cerebral Palsy

Hereditary spastic paraplegias are a clinically and genetically heterogeneous group of disorders characterized by lower extremity spasticity and weakness. Recently, the first de novo mutations in KIF1A were identified in patients with an early-onset severe form of complicated hereditary spastic paraplegia. We report two additional patients with novel de novo mutations in KIF1A, hereby expanding...

Tropical rainforest is largely restricted in Australia to the fairly continuous Wet Tropics region and disconnected patches to the north on Cape York. The Wet Tropics is relatively well explored and studied, whereas the rainforests of Cape York have received less attention due to their remoteness. Here we describe two new species of Glaphyromorphus skinks from rainforest areas on Cape York. The...

Objective To investigate the feasibility and effectiveness of a home-based exercise program in TSP/HAM individuals. Methods Twenty-three TSP/HAM individuals divided in two groups according to Timed Up and Go (TUG) score (<20s vs ≥20s) performed a 20-week home-based exercise program. The primary outcomes were exercise adherence, maximum voluntary isometric contraction of lower limbs (MVIC), Ba...

Background: Stroke patients generally have disorders related to decreased functionality, motor disturbances being the most common. One symptom of stroke is sudden weakness one side body on face, arms and legs. Central post-stroke pain a condition central neuropathic arising directly from lesions cerebrovascular somatosensory nervous system. Mirror therapy non-pharmacological in form imaging lim...

Over the years, most often surgical management of cerebral palsy (CP) has focused only on lower extremities wherein surgeries are performed regularly for sitting, standing and ambulation. Upper extremity surgery is uncommonly done to improve functions hand. To study effectiveness tendon transfers in upper spastic hemiplegia This was a prospective study, which included 24 patients with hemiplegi...

Hereditary spastic paraplegia (HSP) is a neurodegenerative disease characterized by progressive spasticity in the lower extremities. Mutations in the atlastin GTPase 1 (ATL1) gene cause approximately 10% of autosomal dominantly inherited HSP. For many subjects with an ATL1 mutation, spastic gait begins in early childhood and does not significantly worsen, even over many years; such cases resemb...