Evidence from prospective and retrospective clinical trials suggests that for infants <2 months old, only those at high risk for serious bacterial infection by standardized criteria (eg, Rochester classification) require lumbar puncture (strength of recommendation [SOR]: B, based on prospective and retrospective cohort studies). However, expert opinion suggests lumbar puncture on all infants ag...

Sulfate (SO42-) and nitrate (NO3-) are the main secondary inorganic components in atmospheric particulates. It is of great significance to understand formation evolution air pollution process pollution. In this study, samples PM10 were collected Jinhua City eastern China from December 2019 January 2020 June August 2020, also analyzed influence different meteorological conditions gaseous polluta...

Tislelizumab (TIS), an anti-PD-1 monoclonal antibody, has demonstrated durable responses and was well tolerated as monotherapy in 2L+ treatment patients (pts) previously treated systemically for unresectable HCC (Ducreux et al, 2021). TIS been further evaluated against sorafenib (SOR) a global randomized Phase 3 study (RATIONALE-301; NCT03412773) 1L adult pts with HCC. Systemic therapy-naïve ad...

The Service-oriented Router (SoR), a highly functional router based on a novel router architecture, enables unprecedented web services traditional routers were unable to provide. The SoR performs Deep Packet Inspection (DPI) to analyze Layer 7 information, which is becoming increasingly difficult due to the substantial increase in Internet traffic. Meanwhile, multi-core processors and general-p...

The active site of superoxide reductase SOR consists of an Fe2+ center in an unusual [His4 Cys1] square-pyramidal geometry. It specifically reduces superoxide to produce H2O2. Here, we have reacted the SOR from Desulfoarculus baarsii directly with H2O2. We have found that its active site can transiently stabilize an Fe3+-peroxo species that we have spectroscopically characterized by resonance R...

Cell sor ting of biologic specimens by flow cytometry has become a widely used technique in r esear ch and clinical laborator ies. Because viable biologic specimens can contain infectious agents, pr ecautions need to be taken to prevent the exposure of operators of flow cytometers to biohazards ar ising from the use of these instruments. The International Society of Analytical Cytology (ISAC) r...

A mixed effect model describing median overall survival (mOS) in patients with advanced hepatocellular carcinoma (aHCC) treated with antiangiogenic therapy (AAT) was developed from literature data. Data were extracted from 59 studies, representing 4,813 patients. The final model included estimates of mOS after AAT (8.5 months) or placebo (7.1 months) administration. The mOS increased 21% when t...

BACKGROUND Sensory over-responsivity (SOR) affects many individuals with autism spectrum disorders (ASD), often leading to stressful encounters during daily routines. METHODS This study describes the associations between early SOR symptoms and the longitudinal course of restrictions in family life activities and parenting stress across three time-points in families raising a child with ASD (n...

Superoxide reductases (SORs) are nonheme iron-containing enzymes that reduce HO(2) to H(2)O(2). Exogenous substrates such as N(3)(-) and CN(-) have been shown to bind to the catalytic iron site of SOR, and cyanide acts as an inhibitor. To understand how these exogenous ligands alter the physical and reactivity properties of the SOR iron site, acetate-, azide-, and cyanide-ligated synthetic mode...

OBJECTIVE The aim of this study was to report and compare the anatomic and functional results of primary vitrectomy with and without 360° encircling scleral buckle (SB) for the treatment of rhegmatogenous retinal detachment (RRD) due to inferior retinal break(s). BACKGROUND A variety of options, including SB, pars plana vitrectomy (PPV) with or without SB, and pneumatic retinopexy have been d...