نتایج جستجو برای: somatic antigens
تعداد نتایج: 157498 فیلتر نتایج به سال:
Filariasis is a serious health hazard affecting millions of people in tropical and subtropical regions of developing countries including India. The specific diagnosis and control measures are essential for effective management of the disease. It has been shown earlier that the excretorysecretory products of filarial parasitescontain diagnostically important embryo antigens; therefore, it would ...
The major histocompatibility class I antigens, expressed in most somatic cells, have carbohydrate moieties. We constructed mutant mouse MHC class I genes in which codons for the N-linked glycosylation sites were replaced by those of other amino acids. L cell transformants expressing the nonglycosylated class I antigens allowed us to investigate biological roles of carbohydrates with the highest...
Pure spore antigens for the immunization of rabbits were prepared by enzymic digestion of vegetative components and separation of the cleaned spores in polyethylene glycol. Spore antisera were prepared to strains representative of toxigenic Clostridium botulinum type E; nontoxigenic boticin E-producing variants; nontoxigenic nonproducers of boticin E; nontoxigenic "atypical" strains, which diff...
Unlike other somatic cells, human placental trophoblast cells do not express the highly polymorphic HLA-A and HLA-B human leukocyte major histocompatibility antigens that would stimulate maternal immunological rejection of the fetus. To investigate mechanisms underlying cell lineage-specific expression, cell lines were generated from homozygous matings of HLA-B27 transgenic mice. Trophoblast ce...
سرطان عامل اصلی مرگ در کشورهای توسعه یافته اقتصادی و دومین عامل مرگ در کشورهای در حال توسعه است. سرطان کولورکتال یکی از سومین سرطان رایج و چهارمین دلیل مرگ و میر در جهان است. سرطان کولورکتال در ایران، در مردان، چهارمین سرطان بوده و در زنان دومین سرطان محسوب می¬شود. بیشترین مرگ و میر ناشی از سرطان کولورکتال به علت متاستاز دادن آن است. تشخیص زود هنگام و اتخاذ روش های درمانی مناسب برای این افراد ا...
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be protective, but this has not been achieved. To explore immunization regimens that might elicit bNAbs, we produced and immunized mice expressing the predicted germline PGT121, a bNAb specific for the V3-loop and surrounding glycans on the HIV-1 spike. Priming with an epitope-modified immunogen designed t...
B cells use translesion DNA synthesis (TLS) to introduce somatic mutations around genetic lesions caused by activation-induced cytidine deaminase. Monoubiquitination at lysine(164) of proliferating cell nuclear antigen (PCNA(K164)) stimulates TLS. To determine the role of PCNA(K164) modifications in somatic hypermutation, PCNA(K164R) knock-in mice were generated. PCNA(K164R/K164R) mutants are b...
Analysis of somatic mutations in V regions of Ig genes is important for understanding various biological processes. It is customary to estimate Ag selection on Ig genes by assessment of replacement (R) as opposed to silent (S) mutations in the complementary-determining regions and S as opposed to R mutations in the framework regions. In the past such an evaluation was performed using a binomial...
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