Synthetic biology offers a new path for the exploitation and improvement of natural products to address the growing crisis in antibiotic resistance. All antibiotics in clinical use are facing eventual obsolesce as a result of the evolution and dissemination of resistance mechanisms, yet there are few new drug leads forthcoming from the pharmaceutical sector. Natural products of microbial origin...

A synthesis of carolacton, a myxobacterial natural product that has profound effects on Streptococcus mutans biofilms, is reported. The synthesis proceeds via a longest linear sequence of 14 steps from an Evans β-ketoimide and enabled preliminary evaluations of the effects of late-stage intermediates on S. mutans biofilms. These studies suggest that further investigations into carolacton's stru...

Background: Considering the toxic effects of heavy metals and microbial pathogens in industrial wastewaters, it is necessary to treat metal and microbial contaminated wastewater prior to disposal in the environment. The purpose of this study is to assess the removal of heavy metals pollution and microbial contamination from a mixture of municipal and industrial wastewater using membrane biorea...

the usage of antimicrobial materials for coating meat products, in addition to reducing the microbial population and increase of the quality safety of products, be greatly reduced usage of nitrites as preservatives and synthetic carcinogens. compounds that have antimicrobial activity can be mixed, stabilized or incorporated with edible coatings. spices and vegetable extracts are also a group of...

Wound healing continues to pose a challenge in clinical settings. Moreover, wound management must be performed properly and efficiently. Acute involves multiple cell divisions, new extracellular matrix, the process of formation, such as growth factors cytokines, which are released at site regulate process. Any changes that disrupt could cause tissue damage prolong Various factors, microbial inf...

The notion that the colon's deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.