Gene silencing mediated by small interfering RNA (siRNA) is a novel approach in the development of new cancer therapeutics. Polycations used for nucleic acid delivery still remain heterogeneous compounds, despite continuous progress in polymer synthetic technologies. Here we report the development of a structural defined folic acid polyethylene glycol (PEG) siRNA conjugate accessible via click ...

Ursolic acid is a promising candidate for treatment of Chagas disease; however it has low aqueous solubility and intestinal absorption, which are both limiting factors for bioavailability. Among the strategies to enhance the solubility and dissolution of lipophilic drugs, solid dispersions are growing in popularity. In this study, we employed a mixture of the surfactants poloxamer 407 with sodi...

A simple and reproducible method for altering the acyl chain composition of Chinese hamster ovary cell phospholipids is described. By supplementation of the medium with 5% delipidized serum and 12 pg/ml of various fatty acids, extensive incorporation of the added fatty acid into membrane phospholipids was obtained. No significant changes in the phospholipid head group composition or the sterol/...

Lilium ledebourii (Baker) Boiss. (Liliaceae) is a critically endangered lily species native tonorthern Iran, where it is protected by law. In order to develop a cost effective method for largescalepropagation, the effects of three culture systems (solid, liquid and temporary immersion)and two types of cytokinins [6-Benzyladenine (BA) and Thidiazuron (TDZ)] were studied onthe in vitro plant rege...

an ion chromatography (ic) method for simultaneous determination of benzoic, salicylic and sorbic acids was developed. in this method the samples were purified by solid-phase extraction. the analytes were then eluted with methanol from c18 cartridge. the separation was performed on ion-exclusion column by an isocratic elution with 0.25 mmol /l sulfuric acid solution containing 20% (v/v) acetone...

in this study, the effect of edible coating and osmotic dehydration, as pre-treatments before drying of cucurbit, were investigated. cucurbit samples were cut spirally and coated by carboxy methyl cellulose (cmc) 1% and ascorbic acid 0.1% solutions and then processed by osmotic dehydration. proportion of sample to solution was 1:10 and the solution containing sucrose %45, salt%25 and citric aci...

This paper investigated the effect of Pr₆O11 addition on the acid resistance of ceramic proppant. Acid resistance of proppants can be improved by introducing Pr₆O11 into the Al₂O₃-CaO-MgO-SiO₂ (ACMS) system. To illustrate and explain the mechanism of acid resistance, the samples were characterized by different techniques, using X-ray powder diffraction (XRD) and scanning electron microscopy (SE...

kaolin-so3h as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. this natural based catalyst is very inexpensive and easy available. imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, anti...

Abstract Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic,anti-infammatory and antipyretic actions. It is used to relieve mild to moderate pains. Solid-phase extraction of mefenamic acid by a polymer grafted to silica gel is reported . Poly allyl glycidyl ether/iminodiacetic acid-co-N, N-dimethylacrylamide was synthesized and grafted to silica gel and was used ...