According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) depression is considered a mental state of altered mood characterized by sadness, desperation, anhedonia and decreased interest in daily life activities, subjective sensation of discomfort, feelings of worthlessness and lack of self-esteem. Therefore apathy can be an aspect of depression in the manner in which there ...

Abstract Background Apathy is one of the most common Neuropsychiatric Symptom (NPS) and associated with poor clinical outcomes. remains under‐researched its medical classification unclear, potentially fact that apathy commonly a comorbidity depression. Research helps define phenotype urgently needed, particularly for biomarker studies. Method Using latent class analysis (LCA) we analysed data f...

BACKGROUND Although several prior works reported that apathy is associated with conversion to Alzheimer's disease in individuals with amnestic mild cognitive impairment (aMCI), effects of apathy on the functional connectivity (FC) of the brain remain unclear. In this study, we assessed the pattern of association between apathy and default mode network (DMN), salience network and central executi...

In this paper we will reconsider the dichotomy of "perspective" that conventionally informs most methodological discussions. This dichotomy separates the perspective of the actor from the perspective of the social scientist and is a crucial premiss of positivistic social science. It is not the separation of actor and scientist that is problematic; if the activities of the scientist are not negl...

Abstract Although the term of amyotrophic lateral sclerosis (ALS) is often used interchangeably with motor neuron disease, ALS universally accepted as a multisystem disorder. Cognitive impairment an acknowledged feature ALS, affecting language, memory and behaviour, apathy considered to be prevalent behavioural alteration in ALS. It can divided three subtypes: executive, emotional initiation ap...

OBJECTIVE To identify distinct behavioral phenotypes of behavioral-variant frontotemporal dementia (bvFTD) and to elucidate differences in functional, neuroimaging, and progression to residential care placement. METHODS Eighty-eight patients with bvFTD were included in a cluster analysis applying levels of disinhibition and apathy (Cambridge Behavioural Inventory-Revised) to identify phenotyp...

In 1958, Corbu advocated a ‘new architecture’ for a ‘new man’. The omnipresence of the architect creating spaces to model a society led to architects building many sins. After that the influence of architecture in the lives of its inhabitants began to be a subject ignored. A lot of contemporary architecture limited itself to the production of design or service to capital of the day. In 1...