Analysis of DNA from the mucosal tissue of three patients with immunoproliferative small intestinal disease (IPSID) and alpha chain disease, two of whom had early stage disease responsive to antibiotics, showed monoclonal heavy and light chain gene rearrangements in all cases. These findings suggest that IPSID is neoplastic even in its early stages, but that the neoplastic cells respond to norm...

A group of 21 patients with immunoproliferative small intestinal disease (IPSID), 10 with alpha heavy chain paraproteinaemia and 11 without it, were HLA typed. The results were compared with 35 disease controls and 120 normal controls. A significant increase of Aw19 and B12 antigens was noted among the patients compared with the control subjects. The high rate of association of both AW19 and B1...

A standardized oral fat load has been given to 66 children having duodenal or jejunal biopsy, and to 10 children presumed normal. The rise in plasma light scattering intensity (LSI) measured by nephelometry between the fasting and 2-hour postload level (0-2 hour) showed good correlation with the small intestinal morphology in patients suspected of having coeliac disease. In those who had had re...

celiac disease (cd) is an autoimmune enteropathy induced by the ingestion of gluten in genetically predisposed individuals who carry the hla dq2 or dq8 alleles. the etiology is multifactorial involving genetic and environmental factors, immune response, and intestinal dysbiosis. the innate and acquired t-cell mediated immunity play important roles in the pathogenesis of this disease, particular...

BACKGROUND Although Crohn's disease (CD) is thought to predispose to adenocarcinomas of the small bowel, the association has not been well studied in an older population. AIMS The objective of our study was to evaluate the association of CD with small bowel cancer in a population-based case-control study. METHODS All cases of small bowel cancer in persons 67 and older in the Surveillance, E...

abstract background and objective: celiac is an autoimmune disease that is characterized by an immune-system-related damage in the intestinal tissue after consumption of gluten. there is not any general agreement for gold standard. the purpose of this study was the evaluation of specificity and sensitivity of anti-endomysial (ema) and anti-tissue transglutaminase (ttg) serological test compared...

Coeliac disease is associated with an increased risk of malignancy, not only of intestinal lymphoma but also of small intestinal adenocarcinoma which is 82 times more common in patients with celiac disease than in the normal population. We report three additional cases of a small bowel adenocarcinoma in the setting of coeliac disease in order to underline the epidemiological features, clinicopa...

Obstruction is the most common surgical disorder of the small bowel. Complete small bowel obstruction (SBO) is usually treated surgically because bowel strangulation cannot be excluded with certainty. Acute SBO has been previously considered a relative contraindication for laparoscopic management especially due to the laparotomy conversion rate. We present a case of SBO for which laparoscopic m...

BACKGROUND/AIMS Crohn's disease (CD) is a chronic inflammatory bowel disease that presents with variable features and repeated disease aggravation. The incidence of CD is increasing in Korea. We evaluated the clinical features of CD in a study population in Busan and Gyeongnam, Korea. METHODS A hospital-based analysis included 619 patients diagnosed with CD between March 1986 and February 201...

Introduction Small bowel transplantation is a curative procedure for the treatment of irreversible intestinal failure with the complications of parenteral nutrition or for extensive intraabdominal disease requiring evisceration. 26 isolated small bowel transplants were performed in the UK in 2014 [1]. With advances in surgical techniques and the evolution of immunosuppressants, notably monoclon...