HLA DQB1*0602 is found in most individuals with hypocretin-deficient narcolepsy, a disorder characterized by a severe disruption of sleep and wake. Population studies indicate that DQB1*0602 may also be associated with normal phenotypic variation of rapid eye movement (REM) sleep. Disruption of REM sleep has been linked to specific symptoms of insomnia. We here examine the relationship of sleep...

OBJECTIVES We examined temporal associations between objectively-measured physical activity (PA) during the day and in the evening, and sleep quantity and quality. STUDY DESIGN PA and sleep were measured by actigraphs for an average of one week in an epidemiological cohort study of 275 eight-year-old children. RESULTS For each one standard deviation (SD) unit of increased PA during the day,...

OBJECTIVE This study aims to assess the relationship of late-night cell phone use with sleep duration and quality in a sample of Iranian adolescents. METHODS The study population consisted of 2400 adolescents, aged 12-18 years, living in Isfahan, Iran. Age, body mass index, sleep duration, cell phone use after 9p.m., and physical activity were documented. For sleep assessment, the Pittsburgh ...

Neurexins are cell adhesion molecules involved in synaptic formation and synaptic transmission. Mutations in neurexin genes are linked to autism spectrum disorders (ASDs), which are frequently associated with sleep problems. However, the role of neurexin-mediated synaptic transmission in sleep regulation is unclear. Here, we show that lack of the Drosophila α-neurexin homolog significantly redu...

The link between sleep and aging is a hot topic of research. On the one hand, much attention has been paid to epidemiological studies showing that both short sleep and long sleep in humans are associated with reduced longevity. I will briefly review this literature and discuss recent experiments in the fruit fly Drosophila melanogaster that may contribute to understanding this complicated assoc...

AIMS To investigate the effect of alcohol consumption on the sleep and mood of healthy individuals in a college-based, mixed gender population. METHODS Forty-seven individuals participated in this study, of whom 33 consumed alcohol and were included in the analysis. Sleep quality was objectively recorded using actigraphy. Subjects completed a daily sleep diary and bipolar Profile of Mood Stat...

There is now an overwhelming preponderance of evidence that cognitive behavioural therapy for insomnia (CBT-I) is effective, as effective as sedative hypnotics during acute treatment (4-8 weeks), and is more effective in long term (following treatment). Although the efficacy of CBT-I in the treatment of chronic insomnia is well known, however there is little objective data on the effects of CBT...

OBJECTIVES Many studies have evaluated the ways in which sleep disturbances may influence inflammation and the possible links of this effect to cardiovascular risk. Our objective was to investigate the effects of chronic sleep restriction and recovery on several blood cardiovascular biomarkers. METHODS AND RESULTS Nine healthy male non-smokers, aged 22-29 years, were admitted to the Sleep Lab...

At a time when several studies have highlighted the relationship between sleep, learning and memory processes, an in-depth analysis of the effects of sleep deprivation on student learning ability and academic performance would appear to be essential. Most studies have been naturalistic correlative investigations, where sleep schedules were correlated with school and academic achievement. Noneth...

Background: Recent evidence shows that epileptiform activity (EA) in sleep can present early Alzheimer’s Disease (AD) with faster cognitive decline. Existing literature examining sleep, AD and seizures is mostly qualitative. We conducted a systematic review to quantify the stage most associated EA amnestic mild impairment (aMCI)Methods: searched MEDLINE Embase using MeSH terms: “Alzheimer’s Dis...