accelerating wound healing is now considered as a principle clinical treatment and increasing the quality and speed of healing which has always been emphasized by the scientists. propolis and honey are natural bee products with wide range of biological and medicinal properties. this study was aimed to determine the synergistic effect of honey and propolis in wound healing of rat skin. a total o...

Skin homeostasis is maintained by controlling the balance between proliferation and differentiation of epidermal stem cells. The microenvironment, including extrinsic stresses, growth factors, soluble molecules, cell-ECM and cell-cell communications, plays an important role in cell fate determination in vivo and in vitro. In response to external signals, keratinocytes cooperate with other cell ...

Skin wounds are categorized as 'acute' or 'chronic' based on the healing process. Wound care is of utmost importance break in skin barrier exposes internal milieu to various commensal and pathogenic microbes. The usage nanomaterials a recent approach facilitate wound by processes that operate singly tandem. Metal show antibacterial, antifungal, anti-inflammatory activities; organic-inorganic, o...

This clinical trial aimed to evaluate the efficacy and safety of a novel wound dressing composed of hyaluronic acid (HA) and collagen (Col) containing epidermal growth factor (EGF), referred to as EGF-wound dressing. EGF-wound dressing was prepared by freeze-drying a mixed aqueous solution of high-molecular-weight HA, low-molecular-weight HA and heat-denatured Col containing EGF. EGF-wound dres...

PURPOSE The purpose of this study was to determine the effect of the angiogenesis inhibitor endostatin on blood vessels in tumors and wound sites. EXPERIMENTAL DESIGN In a Phase I dose escalation study, cancer patients were treated with daily infusions of human recombinant endostatin. Tumor biopsies were obtained prior to and 8 weeks after initiation of treatment. Blood vessel formation in no...

Loss of cutaneous innervation from sensory neuropathy is included among mechanisms for impaired healing of diabetic skin wounds. The relationships between cutaneous axons and their local microenvironment during wound healing are challenged in diabetes. Here, we show that secondary wound closure of the hairy dorsal skin of mice is delayed by diabetes and is associated with not only a pre-existin...

HYPOTHESIS Application of skin sealant prior to incision reduces microbial contamination of the wound. DESIGN Prospective, randomized, multicenter clinical trial. SETTING Six teaching hospitals. PATIENTS A total of 177 adult patients undergoing elective open inguinal hernia repair were randomized to either standard skin preparation with 10% povidone-iodine or skin preparation followed by ...

PURPOSE To provide the wound care practitioner with an updated overview of the epidemiology, clinical presentation, treatment, and prevention of skin cancer. TARGET AUDIENCE This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES After participating in this educational activity, the participant should be better able to: 1....

In the 1960s, Winter (1962) identified that moisture was required to provide an optimum environment for reepithelialisation (and hence healing) to occur. Since then, further research has added to our knowledge and now the broad criteria for an ideal wound dressing includes: Provision of a moist environment Protection from the external environment (including the prevention of ingress of foreign ...