There is an urgent need for an immunological correlate of protection against tuberculosis (TB) with which to evaluate candidate TB vaccines in clinical trials. Development of a human challenge model of Mycobacterium tuberculosis (M.tb) could facilitate the detection of such correlate(s). Here we propose a novel in vivo Bacille Calmette-Guérin (BCG) challenge model using BCG immunization as a su...

Tuberculin skin test (TST), an age old method is based on measuring delayed-type hypersensitivity (DTH) response to purified protein derivative (PPD). However, inspite of simplicity, ease and cost effectiveness, the usefulness of PPD test is limited due to its inability to distinguish among a protective immune response, latent infection and active tuberculosis disease. On the other hand, a skin...

In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune respon...

Tuberculosis is caused by Mycobacterium tuberculosis. The approach to testing for tuberculosis depends on whether the aim is to diagnose active disease or latent infection. if active disease is suspected, it is important to identify the site of disease. Analysis of sputum specimens for mycobacteria should precede other tests. An infection should never be diagnosed as latent until active disease...

Tuberculosis still maintains its place among important diseases today. This is becoming a problem not only in developing countries but also developed countries. Upper respiratory tuberculosis rare our country. bacillus can settle the mouth, tonsils, tongue, nose, epiglottis, larynx, and pharynx. A 16-year-old female patient living dormitory was admitted to clinic with complaint of tonsillitis r...

tuberculosis (tb) is an important health problem in developing countries, with varying clinical presentations depending on the organs/systems involved. to study the spectrum of clinical and paraclinical aspects of extra pulmonary tb in children suffering from pulmonary tb. this study has been carried out on 65 children with tuberculosis, admitted in tb wards of national research institute of tu...

Occurrence of pulmonary tuberculosis with leprosy is known but association of cutaneous tuberculosis with leprosy is rare. We report a case of borderline lepromatous leprosy coexistent with tuberculosis verrucosa cutis in a 29-year-old male, who presented with multiple skin coloured nodules and hyperkeratotic scaly lesions of 3-month duration. Dual infections are associated with high mortality ...

AlL positive diagnosis of active pulmonary tuberculosis can be made only on obtaining a positive sputum or gastric culture for M tuberculosis. The chest x-ray film and tuberculin skin test1 have been used as screening methods. During the third year after the introduction of the acetylcysteine method of digestion at our facility,* 40 cases of active tuberculosis with chest x-ray films read as ne...

OBJECTIVE To evaluate an interferon (IFN)-gamma release assay in diagnosing latent tuberculosis infection in pregnant adolescents and women at risk for exposure to Mycobacterium tuberculosis. METHODS This was a prospective study of women and adolescents receiving health care at Bellevue Hospital Outpatient Clinics in New York City. Each patient was assessed for M tuberculosis risk factors, ha...