INTRODUCTION Pressure ulcers represent a significant cause of morbidity and health care expenditure in the United States. A pressure ulcer is a lesion of localized injury to the skin or underlying tissue, usually over a bony prominence, resulting from pressure alone or in combination with shear forces. Ulcers are staged based on depth of tissue involvement. Using the revised National Pressure U...

Skin, the largest organ of the human body, is organized into an elaborate layered structure consisting mainly of the outermost epidermis and the underlying dermis. A subcutaneous adipose-storing hypodermis layer and various appendages such as hair follicles, sweat glands, sebaceous glands, nerves, lymphatics, and blood vessels are also present in the skin. These multiple components of the skin ...

Managing major pediatric burns remains a challenge for the entire multidisciplinary team. Limited donor sites make complete early wound closure impossible and need temporary cover options ideally autologous cultured skin increases. We report case of 5 year-old child with 95% total body surface area (TBSA) deep flame burn large scale application laboratory grown, dermo-epidermal analogue, termed...

Fodd Scientists and technologists have long been searching for fat su bstitutes, i.e. compounds with physical and organoleptic properties similar to conventional dietary fats and oils but with as few calories as possible. After many years of persistant efforts, they have recently achieved considerable sussess in this field. Since a diet high in fat and cholesterol is regarded as an important fa...

BACKGROUND Skin grafting is a relatively simple and thus widely used procedure. However, the elastic and structural quality of grafted skin is poor. Recently, various dermal substitutes have been developed to overcome this disadvantage of split-thickness skin grafts. The present study aims to determine the feasibility of RapiGraft as a new dermal substitute. METHODS This prospective study inc...

Skin color is one of the most distinct features in the human race. To assess the mechanisms of skin color variation, human skin substitutes (HSS) were constructed by grafting mixtures of cultured keratinocytes and melanocytes from a combination of donor skin types, together with light skin derived fibroblasts, into chambers inserted onto the back skin of severe combined immunodeficient (SCID) m...

Traumatic injury represents the most common cause of death in ages 1 to 44 years and asignificant proportion of patients treated in hospital emergency wards each year. Unfortunately, for patients who survive their injuries, survival is not equal to complete recovery. Many traumatic injuries are difficult to treat with conventional therapy and result in permanent disability. In such situations, ...

The main goal in burn management has always been increasing the survival of severely burned patients by rapid debridement and early closure of burn wounds, consequently reducing the risk of infection, sepsis and multi-organ failure. However, in the last decennia, surgical emphasis has shifted from survival to ‘quality of survival’, especially by improving the residual scars and preventing secon...

Daruharidra (Berberis aristata DC) has been used in ayurveda and traditional Chinese medicine for more than 3000 years. It is a red-listed endemic medicinal plant species of conservation concern and has become very important in recent years due to its rarity and huge demand in the medicinal plant sector. However, many other species such as Berberis asiatica Roxb., Berberis lycium Royle., Cosini...