نتایج جستجو برای: skin sensitization
تعداد نتایج: 208578 فیلتر نتایج به سال:
The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of an HSEM for nanotoxicity testing. This study was designed to investigate cutaneous toxicity of polystyrene and TiO2 nanoparticles using cultured keratinocytes, an HSEM, and an animal model. In addition, we also e...
Kojic acid functions as an antioxidant in cosmetic products. Kojic acid was not a toxicant in acute, chronic, reproductive, and genotoxicity studies. While some animal data suggested tumor promotion and weak carcinogenicity, kojic acid is slowly absorbed into the circulation from human skin and likely would not reach the threshold at which these effects were seen. The available human sensitizat...
A Boivin preparation of Brucella abortus, unlike common enterobacterial endotoxins, failed to depress water intake or increase numbers of hemolysin-producing spleen cells in mice, or to cause delayed inflammatory reactions in rabbit skin. Reactivity to the B. abortus endotoxin was found only in animals which were previously given the endotoxin with, but not necessarily in, complete Freund's adj...
INTRODUCTION Heat/capsaicin skin sensitization is a well-characterized human experimental model to induce hyperalgesia and allodynia. Using this model, gabapentin, among other drugs, was shown to significantly reduce cutaneous hyperalgesia compared to placebo. Since the larger thermal probes used in the original studies to produce heat sensitization are now commercially unavailable, we decided ...
autoerythrocyte sensitization syndrome cabs) is a rare purpuric disorder of women characterized by inflammatory and painful ecchymotic lesions unrelated to blood clotting or vascular abnormalities. gastrointestinal bleeding, hematuria, headache or syncopal attacks may also be observed. our patient is a 33-year-old woman presenting with recurrent severe painful ecchymotic lesions on both lower e...
Chlorhexidine is widely used as an antiseptic and disinfectant in medical and nonmedical environments. Although the sensitization rate seems to be low, its ubiquitous use raises the possibility of sensitization in many patients and medical care workers. We describe a patient with anaphylaxis during digital rectal examination with chlorhexidine jelly. Urticaria, angioedema, dyspnea, and hypotens...
Rabbits (and human beings) differ widely in the rapidity with which they undergo sensitization with heat killed tubercle bacilli, but after repeated injections all animals become sensitized. Intracutaneous injection of a small quantity of heat killed tubercle bacilli into a previously normal animal produces a nodule which persists from 8 to 12 weeks; the same injection into well sensitized anim...
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