In one of his scholarly and thoughful essays Dr. Parkes Weber (1946) comments on the great reserve power of various organs in the ordinary healthy young adult, who seldom has to call upon the full reserves of heart or brain, for example; but in times of abundance he may sorely tax his alimentary resources and lead the life of a " digestive athlete." One might remark that the skin has plenty in ...

Primary psychiatric disorders where skin changes appear most frequently include: delusions of parasitosis, body dysmorphic disorder, neurotic excoriations, dermatitis artefacta, and trichotillomania. In all these diseases the primary pathologic condition is of psychiatric nature, and the skin changes are secondary and self-induced. In this review we wanted to present the epidemiology, clinical ...

Keratotic lesions on the plantar aspect of the foot develop beneath an osseous prominence and can result in substantial disability. This occurs because, during normal gait, the metatarsal head area is subjected to more prolonged stress than any other area on the plantar aspect of the foot. In the treatment of this disorder, it is imperative to establish the etiology, among many possibilities, a...

Monoclonal gammopathy represents a condition characterized by clonal proliferation and accumulation of immunoglobulin producing B-cells. A variety of skin disorders are associated with an increased level of monoclonal immunoglobulin proteins. These skin disorders can be divided into two groups. The first group represents a direct consequence of plasma cell proliferation. The colonization of the...

Helicobacter pylori is a Gram-negative bacterium that has been linked to peptic ulcer disease, gastric lymphoma, and gastric carcinoma. Apart from its well-demonstrated role in gastroduodenal diseases, some authors have suggested a potential role of Helicobacter pylori infection in several extra-intestinal pathologies including haematological, cardiovascular, neurological, metabolic, autoimmune...

P LAQUE PSORIASIS (PP) AND LICHEN RUBER planus (LP) are inflammatory skin disorders that can sometimes be clinically difficult to differentiate. In these instances, punch biopsy with subsequent histopathologic evaluation is usually needed. Recently, dermoscopy has been reported to be helpful in the distinction between these 2 entities. The lesions in Figure 1 and Figure 2 were plaques located o...

iabetes Mellitus (DM) refers to a group of metabolic disorders with a common presentation of hyperglycemia. There are two common types of DM. In Type 1, there is absolute or neartotal insulin deficiency; while in type 2, the problem originates from insulin resistance, impaired insulin secretion and raised glucose production (1). Skin disorders are common in diabetic patients and the prevalence ...

The aim of this article was to investigate the frequency, severity and diversity of peristomal skin disorders among individuals with a permanent stoma in a community population. All individuals with a permanent stoma (n=630) in a Danish community population were invited to participate in a cross-sectional study. A total of 202 individuals (101 men; 101 women) agreed to participate. Data were co...

For at least half a century, noninvasive techniques have been available to quantify skin barrier function, and these have shown that a number of human skin conditions and disorders are associated with defects in skin permeability. In the past decade, several genes responsible for skin barrier defects observed in both monogenetic and complex polygenic disorders have been elucidated and functiona...