There were 347 abdominal operations per formed in the Miraj Hospital in 1915 excluding hernias. The following notes and observations pertain only to those included under "Abdominal," 212 cases in all, from which certain series are selected for comments. The 135 abdominal operations upon the uterus and appendages will be reserved for a future communication. Before referring to the different grou...

The skin epidermis is a stratified epithelium that forms a barrier that protects animals from dehydration, mechanical stress, and infections. The epidermis encompasses different appendages, such as the hair follicle (HF), the sebaceous gland (SG), the sweat gland, and the touch dome, that are essential for thermoregulation, sensing the environment, and influencing social behavior. The epidermis...

Ceramides and their metabolites are important for the homeostasis of the epidermis, but much remains unknown about the roles of specific pathways of ceramide metabolism in skin biology. With a mouse model deficient in the alkaline ceramidase (Acer1) gene, we demonstrate that ACER1 plays a key role in the homeostasis of the epidermis and its appendages by controlling the metabolism of ceramides....

Lichen planus (LP) is a chronic lichenoid inflammatory disorder of the skin, mucosa and appendages. LP classically characterized by presence rich infiltration T cells, which migrate in upper part dermis, arranged band-like pattern. Different sub types disease have been so far described. Albeit clinically well defined, still represents therapeutic enigma. Especially with regard to mucosal or sca...

Dermatological diseases, besides involving the skin and its appendages may also involve the oral cavity. The lesions of oral cavity in dermatological disorders deserve special attention, considering that they may be the presenting clinical feature or the only sign of these disorders. Moreover, oral mucosal lesions in skin diseases can be life-threatning and also affect the quality of life in te...

The possibility of the application of autologic pluripotent cells from peripheral blood (APCPB) for correction of striae after pregnancy was studied. Visually first signs of improvement of atrophic scars can be noticed in 6-8 weeks after injection of APCPB and gradually progress during 6 months. The atrophy of epithelium, hyperkeratosis, sclerosis of all dermis layers with smoothing of papillae...

It may appear counter-intuitive to compare feathers and mammary glands. However, through this Evo-Devo analysis, we appreciate how species interact with the environment, requiring different ectodermal organs. Novel ectodermal organs help define evolutionary directions, leading to new organism classes as exemplified by feathers for Aves and mammary glands for Mammals. Here, we review their struc...

Current issues concerning Parasitology and Mycology with regard to diseases of the skin and its appendages are presented. Aspects of diagnostics, clinical picture and therapy of skin and nail mycoses, as well as difficulties in the diagnosis and treatment of both native parasitoses (toxoplasmosis) and imported human tropical parasitoses (malaria, filariosis) have been emphasised. The clinical i...

Peptidylarginine deiminases (PAD) catalyze the conversion of arginine residues to citrullines. Five isoforms are known that present distinct tissue locations. In the epidermis, like in the skin, only PAD1, 2, and 3 are expressed. Their pattern of expression in skin appendages is not known. Here, confocal microscopy analysis using highly specific antibodies demonstrated that PAD1 and 3 are expre...