Body composition is a determinant of performance in soccer. To estimate the body fat percentage (%BF), dual energy X-ray absorptiometry (DXA) effective though this method expensive and not readily accessible. This study examines validity widely used field methods based on anthropometric data bioelectrical impedance analysis (BIA). Participants were 21 male Spanish First Division soccer players ...

Several drugs that block epinephrine synthesis by inhibiting phenylethanolamine N-methyltransferase (PNMT) lower blood pressure in hypertensive rats. We investigated the mechanism by which these drugs lower blood pressure in rats made hypertensive with the glucocorticoid dexamethasone. We performed adrenalectomy or sham operation on several rats and then gave them either dexamethasone chronical...

Introduction: R-[C]-SKF 82957 is a high-affinity and potent dopamine D1 receptor agonist radioligand, which gives rise to a brainpenetrant lipophilic metabolite. In this study, we demonstrate that systemic administration of catechol-O-methyl transferase (COMT) inhibitors blocks this metabolic pathway, facilitating the use of R-[C]-SKF 82957 to image the high-affinity state of the dopamine D1 re...

S 16924 antagonized locomotion provoked by dizocilpine and cocaine, reduced conditioned avoidance responses and blocked climbing elicited by apomorphine, models predictive of control of the positive symptoms of schizophrenia: its median inhibitory dose (ID)50 was 0.96 mg/kg, s.c. vs. 1.91 for clozapine and 0.05 for haloperidol. Rotation elicited in unilateral, substantia nigra-lesioned rats by ...

BACKGROUND AND PURPOSE Excitatory amino acids and their receptors are involved in mediating ischemic neuronal damage. The sigma-agonists are believed to interact with the N-methyl-D-aspartate receptor. Therefore, we studied the neuroprotective, hypothermic, and motor deficit effects of the sigma-agonist SKF 10,047 and the N-methyl-D-aspartate antagonist MK-801. METHODS Neuroprotective effects...

Cognition and Behavior 1) The disruptive effect of instrumental non-contingency on executive functioning. T Gupta, R Toll. From the Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO Previous research has suggested that an inability to learn how to control one’s environment (instrumental non-contingency) has negative effects on cognitive abilities, as demo...

PURPOSE/OBJECTIVES To examine and compare the reliability of four body composition methods commonly used in assessing breast cancer survivors. DESIGN Cross-sectional. SETTING A rehabilitation facility at a university-based comprehensive cancer center in the southeastern United States. SAMPLE 14 breast cancer survivors aged 40-71 years. METHODS Body fat (BF) percentage was estimated via ...

Recent reports have shown that the selective dopamine D(1)-like agonist SKF 83822 [which stimulates adenylate cyclase, but not phospholipase C] induces prominent behavioral seizures in mice, whereas its benzazepine congener SKF 83959 [which stimulates phospholipase C, but not adenylate cyclase] does not. To investigate the relative involvement of D(1) vs D(5) receptors in mediating seizures, et...

Itraconazole and fluconazole have been reported to induce hepatotoxicity in patients. The present study was designed to investigate the role of cytochrome P450 inhibitors, SKF 525A, and curcumin pretreatment on the cytotoxicity of antifungal drugs fluconazole and itraconazole. For 3 consecutive days, female rats were administered daily SKF 525A or curcumin (5 and 25 mg/kg). Control rats receive...