1. García Fernández FJ, Berjón J, Ruíz V, Alcasena MS, Imizcoz MA, Lezáun R. Fibrosis endomiocárdica tropical o enfermedad de Davies. A propósito de un caso. Rev Esp Cardiol. 2001;54:2358. 2. Smedema JP, Winckels SK, Snoep G, Vainer J, Bekkers SC, Crijns HJ. Tropical endomyocardial fibrosis (Davies’ disease): case report demonstrating the role of magnetic resonance imaging. Int J Cardiovasc Ima...

CD44, a transmembrane receptor, is expressed in the standard or variant form and plays a critical role in tumor progression and metastasis. This protein regulates cell adhesion and migration in breast cancer cells. We previously reported that phosphatidylinositol-4-phosphate (PI(4)P) at the Golgi regulates cell migration and invasion in breast cancer cell lines. In this study, we showed that an...

In breast cancers, the large conductance Ca2+ and voltage sensitive K+ (BKCa) channels have been hypothesized to function as oncoproteins, yet it remains unclear how inhibition of channel activity impacts oncogenesis. We demonstrated herein that iberiotoxin (IbTX), an inhibitor of BKCa channels, differentially modulated the in vitro tumorigenic activities of hormone-independent breast cancer ce...

Human macrophages, derived from peripheral blood monocytes, acquire enhanced cytotoxicity for human target cells after incubation in mediator-rich supernates from antigen-stimulated lymphocytes. Maximum cytotoxicity was observed after 24-h incubation in mediators. In comparison to normal macrophages, mediator-activated macrophages were cytotoxic to five of the six malignant cell lines tested bu...

included. References 1. Almeida A, Roberts I. Bone involvement in sickle cell disease. Br J Haematol 2005;129:482-490. 2. Booth C, Inusa B, Obaro SK. Infection in sickle cell disease: a review. Int J Infect Dis 2010;14:e2-e12. 3. Atkins BL, Price EH, Tillyer L, Novelli V, Evans J. Salmonella osteomyelitis in sickle cell disease children in the East End of London. J Infect 1997;34:133-138. 4. Bu...

Characterization of cancer cells is important in case of personalized cancer therapy. Cells can be characterized based on their surface marker expression level using fluorescence or surface-enhanced Raman spectroscopy (SERS) method, but in both cases its needed additional labeling with fluorescent or Raman dyes, those may cause cellular cytotoxicity. In this study, we report silver (Ag) nanosta...

1. Kim CS, Kim JY, Kwon JY, Choi SH, Na S, An J, Kim KJ: Venous air embolism during total laparoscopic hysterectomy: Comparison to total abdominal hysterectomy. ANESTHESIOLOGY 2009; 111:50 – 4 2. Chang DI, Lee MS, Cho SH, Bu SH, Chung SH, Huh SH, Yoon KU, Ahn TB, Yoon SS, Chung KC: Incidence of patent foramen ovale in ischemic stroke patients: A transcranial Doppler study. J Korean Neurol Assoc...

The overexpression and amplification of HER-2 gene is associated with the malignant biological behavior of ovarian carcinoma and these tumor cells expressing elevated levels of HER-2 appear to be resistant to the cytolysis of NK-92. In this study, we analyzed the cytolysis effects of NK-92 on human ovarian carcinoma cells (SK-OV-3) after inhibition the expression of HER-2 mRNA by siRNA. Human o...

In this study, we examined the effects of size, shape, and surface chemistry of gold nanostructures on their uptake (including both adsorption and internalization) by SK-BR-3 breast cancer cells. We used both spherical and cubic Au nanostructures (nanospheres and nanocages, respectively) of two different sizes, and their surface was modified with poly(ethylene glycol) (PEG), antibody anti-HER2,...

The use of natural compounds is promising in approaches to prevent and treat cancer. long-term application most currently employed chemotherapy techniques has toxic side effects. Eugenol, a phenolic phytochemical extracted from certain essential oils, an anti-cancer effect. modulation autophagy can promote either the survival or apoptosis cancer cells. Triple-negative (MDA-MB-231) HER2 positive...