INTRODUCTION Sjögren syndrome (SjS) is a systemic autoimmune disease in which an immunological attack primarily against the salivary and lacrimal glands results in the loss of acinar cell tissue and function, leading to stomatitis sicca and keratoconjunctivitis sicca. In recent years, two genetic regions, one on chromosome 1 (designated autoimmune exocrinopathy 2 or Aec2) and the second on chro...

PURPOSE Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents or inciting drugs. The authors previously reported an association between SJS/TEN and IL-4R gene polymorphism that is essential for IL-4 and IL-13 signaling. To examine IL-4 and IL-13 gene polymorphisms and the combination of these polymorphisms with IL...

Schwartz-Jampel syndrome (SJS) is a rare disorder characterized by micrognathia, kyphoscoliosis, and myotonia. The greatest challenge in the anesthetic management of patients with SJS is performing tracheal intubation. The MultiViewScope (MVS) is a video laryngoscope system in which the video monitor handle can be attached to a stylet scope, laryngoscope blade, or fiberscope. We report a 21-mon...

SJS and TEN are variants of the same process, presenting as severe mucosal erosions with widespread erythematous, cutaneous macules or atypical targets. The cutaneous lesions often become confluent and show a positive Nikolsky sign and epidermal detachment. In SJS, epidermal detachment involves less than 10% of the total body skin area; transitional SJS-TEN is defined by an epidermal detachment...

We herein present a case of a 71-year-old woman with primary Sjogren's syndrome (SjS), who developed bilateral pleural effusion and ground glass opacity during treatment with low-dose prednisolone. The pleural effusion and bronchoalveolar lavage fluid revealed elevation of lymphocytes. Thoracoscopic pleural biopsy showed infiltration of lymphocytes with no evidence of other diseases, confirming...

Aim: Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) is a life-threatening mucocutaneous skin reaction that usually develops against drugs, although there are various factors in its etiology. In this case report, SJS due to antiepileptic drug use will be briefly reviewed. Case:20-year-old female patient was seen the emergency department with generalized tonic-clonic seizure. W...

in this paper, we prove some common fixed point results for two self mappingsf and g on s-metric space such that f is a g.w.c.m with respect to g.

BACKGROUND In adults, erythema multiforme (EM) is thought to be mainly related to herpes infection and Stevens-Johnson syndrome (SJS) to drug reactions. AIMS To investigate this hypothesis in children, and to review our experience in the management of these patients. METHODS A retrospective analysis of 77 paediatric cases of EM or SJS admitted to the Children's Hospital in Bordeaux between ...

Microengraving is a novel technology that uses an array of microfabricated subnanoliter wells to isolate and characterize secreted proteins from larger number of single cells. This printing technique permits the capture and characterization of secreted antibodies on glass slides. Here, we profiled the antigenic repertoires of B cells reacting against salivary gland tissues in Sjögren's syndrome...

Considering the increasing interest in fuzzy theory and possible applications,the concept of fuzzy metric space concept has been introduced by severalauthors from different perspectives. This paper interprets the theory in termsof metrics evaluated on fuzzy numbers and defines a strong Hausdorff topology.We study interrelationships between this theory and other fuzzy theories suchas intuitionis...