There have been few studies on predictive biomarkers that may be useful to select the most suitable opioids optimize therapeutic efficacy in individual patients with cancer pain. We recently investigated of morphine and oxycodone using single nucleotide polymorphisms (SNPs) catechol‑O‑methyltransferase (COMT) rs4680 gene as a biomarker (RELIEF study). To explore additional enable selec...

Sorghum (Sorghum bicolor L.) is a promising biomass crop with high yields of cellulose, hemicellulose, and lignin. has emerged as an eco-friendly industrial material useful for producing biofuels bioplastics. This study conducted genotyping-by-sequencing (GBS)-based genome-wide association studies (GWAS) to establish the genetic basis traits associated biomass. Specifically, researchers evaluat...

Globally terminal drought is one of the major constraints to chickpea ( Cicer arietinum L.) production. Early flowering genotypes escape drought, and increase in seed size compensates for yield losses arising from drought. A MutMap population early large was developed by crossing mutant line ICC4958-M3-2828 with wild-type ICC 4958. Based on phenotyping population, extreme bulks days 100-seed we...

The enormous genetic diversity in South Asia resulting from a long and complex admixture history resulted the emergence of variation various traits variations disease susceptibility. Neuropsychological disorders are one such example that shows at population level. In this study, we aimed understanding neuropsychological level among Asian populations by curating, comparing contrasting single nuc...

Yam bean (Pachyrhizus erosus Rich. Ex DC.) is an underutilized leguminous crop which has been used as a food source across central America and Asia. It adapted to range of environments closely related major crops, offering the potential understand genetic basis environmental adaptation, it may be novel genes alleles for improvement other legumes. Here, we assembled draft genome P. 460 Mbp in si...

Inflammatory bowel disease (IBD) applies to two main forms of chronic relapsing inflammatory intestinal disorders: Crohn's (CD), Ulcerative colitis (UC). CD requires an irregular immune reaction that induces intense inflammation. The cause is not yet fully known; previous research, however, indicated inflammation the intestines elevated or continues due inappropriate responses associations betw...

Natural genetic material may help identify abnormalities and provide insight into the workings of gene expression systems. Disorders associated with chromosomal include single nucleotide polymorphisms (SNPs), minor insertions deletions, significant aberrations. In order to analyse DNA sequences, one most important components biological study, various techniques have been used. Thus, analysis co...

High prevalence of bronchial asthma among the population (about 300 million people all over world) provides rationale for search candidate genes disease. Human acidic chitinase (CHIA (AMCase)), encoded by CHIA gene, is involved in degradation chitin, a component fungal cell wall and arthropod exoskeleton, which, if present food or house dust, provoking factor (BA) development. Functionally sign...

Polymorphisms are DNA variations between different individuals of the same species. There are several types of polymorphisms, including single nucleotide polymorphisms (SNPs), variable number tandem repeats, insertions and deletions, large-scale polymorphisms, and copy number variants. In addition to helping explain the genetic basis of our diversity, understanding polymorphisms is also medical...

Three types of sequence variations--single-nucleotide polymorphisms (SNPs), insertions and deletions (indels), and short tandem repeats (STRs)--have been extensively reported in mammalian genomes. In this study, we discovered a novel type of sequence variation, i.e., multiple-nucleotide length polymorphisms (MNLPs) in bovine UCN3 (Urocortin 3) and its receptor CRHR2 (corticotropin-releasing hor...