Sophorolipids (SLs) are glycolipids produced fermentatively by yeast such as Candida bombicola, Candida apicola and Wickerhamiella domercqiae and composed of a dimeric sugar linked with a glycosidic bond to a hydroxyl fatty acid. SLs have gained interest in pharmaceutical arena because of its wide array of therapeutic benefits. Shah et al. 1 first reported that natural SLs and its first generat...

We investigated flexible liposomes as a potential oral drug delivery system. However, enhanced membrane fluidity and structural deformability may necessitate liposomal surface modification when facing the harsh environment of the gastrointestinal tract. In the present study, silica-coated flexible liposomes loaded with curcumin (CUR-SLs) having poor water solubility as a model drug were prepare...

We showed previously that the intracellular transport of sphingolipids (SLs) is altered in SL storage disease fibroblasts, due in part to the secondary accumulation of free cholesterol. In the present study we examined the mechanism of cholesterol elevation in normal human skin fibroblasts induced by treatment with SLs. When cells were incubated with various natural SLs for 44 h, cholesterol le...

The systemic administration of high dose recombinant interleukin 2 (RIL-2) can mediate significant reductions in the number of hepatic métastases in a murine system. This effect is sensitive to host irradiation. Both large granular (LGLs) and small (SLs) lymphocytes have been implicated as the cells mediating the antitumor effect. Utilizing selective Percoli fractionation of liver nonparenchym...

The systemic administration of high dose recombinant interleukin 2 (RIL-2) can mediate significant reductions in the number of hepatic metastases in a murine system. This effect is sensitive to host irradiation. Both large granular (LGLs) and small (SLs) lymphocytes have been implicated as the cells mediating the antitumor effect. Utilizing selective Percoll fractionation of liver nonparenchyma...

InAs/GaSb type-II strained-layer superlattice (SLS) photovoltaic infrared (IR) detectors are currently of great interest for midand long-wave IR detection. A novel technique of reducing detector dark current by inserting resonant tunnelling barriers into a conventional InAs/GaSb SLS is investigated. The GaSb/InAs/GaSb resonant tunnelling double barrier heterostructure was designed to be periodi...

I give special thanks to Dr Paul Wetter and Janis Chinnock who, beginning in 1988, opened their home and their lives to the foundation of a society that would provide information and education in the field of laparoscopic, endoscopic, and minimally invasive surgery and that would recognize individuals who made an outstanding contribution to that field. That the society exists is a tribute to th...

has indeed been a great pleasure and an honor to have the opportunity to serve as your president during this last year, a special one, I think, as it takes us to the year 2000. As I began my research for this address, I came across this quote from Jacques Perissat, one of the leaders in minimally invasive surgery in Europe, who wrote in the World Journal of Surgery, " For a surgeon who performe...

Summary: Low frequency ultrasound in combination with Sodium Lauryl Sulphate (SLS), a known transdermal chemical enhancer has been found to enhance delivery of molecules through the skin. In this abstract, we report the effects of changing SLS concentration on cavitation, protein permeation through the skin and skin damage. Introduction: Low-frequency ultrasound (US), applied to skin via a liqu...

Colorectal surgeons have many options for minimally invasive surgery (MIS), including standard laparoscopic surgery (SLS), single-port surgery, robotic surgery, a transanal total mesorectal excision (TME), and hand-assisted laparoscopic surgery (HALS). Traditionally, SLS is the most common type of MIS. However, nowadays, MIS using small incisions, for example, single-port surgery and transanal ...