The total synthesis of two key analogues of vancomycin containing single-atom exchanges in the binding pocket (residue 4 amidine and thioamide) are disclosed as well as their peripherally modified (4-chlorobiphenyl)methyl (CBP) derivatives. Their assessment indicates that combined pocket amidine and CBP peripherally modified analogues exhibit a remarkable spectrum of antimicrobial activity (VSS...

Digital photography has made immense progress over the past 15 years, particularly in increasing resolution and improving low-light performance. But continuing progress in these aspects of performance is not possible, because cameras are now approaching the limits imposed by the basic nature of light. This article looks at the physics that explains these limits. It shows how the fact that light...

BACKGROUND Peri-implantitis (PI) is an inflammatory reaction associated with functional deterioration of supporting bones around the dental implant. Recent studies suggested Epstein-Barr virus (EBV) is involved in the pathogenesis of periodontitis. We investigated the association between EBV and Porphyromonas gingivalis in Japanese PI patients. METHODS Fifteen periodontally healthy individual...

OBJECTIVE To determine the association between oxidative stress parameters with periodontal disease, bleeding, and the presence of different periodontal bacteria. METHODS A cross-sectional study in a sample of eighty-six patients, divided into three groups depending on their periodontal status. Thirty-three with chronic periodontitis, sixteen with gingivitis, and thirty-seven with periodontal...

Background and aims. A combination of guided tissue regeneration (GTR), bovine porous bone mineral (BPBM), and platelet rich plasma has been already applied for the regeneration of intrabony defects. The aim of this study was to determine the role of plasma rich in growth factor (PRGF) alone in the periodontal regeneration of intrabony defects in humans as compared with BPBM/GTR Technique. Mate...

Mathematics is in a dramatic and massive process of changing, mainly due to the advent of computers and computer science. Our aim is to present a pocket image of this phenomenon; a “case study” will give us the opportunity to describe some of these new ideas, problems, and techniques. Particularly, we will be concerned with foreseeable mutations in the interaction between deductive and experime...

Pages 179 i have carried this useful book in my pocket and used it with benefit in clinical meetings. It is intended for hospital doctors as a guide to practical management of people with diabetes and endocrine disorders. It describes each gland, the normal function and its variants, the symptoms and signs, the tests which might be used to establish the diagnosis and treatment. There is a sensi...

The aim of this study was to analyze the relationship among the point of greatest depression on the root trifurcation floor and the furcation openings of the maxillary second molars. Sixty human extracted upper permanent second molars were analyzed and the furcation area were measured using a vertical calliper, and the values regarding the point of deepest depression were recorded. The results ...

The correlation between Gram negative enteric rods and Porphyromonas gingivalis in periodontal diseases has received little attention in the literature. The objective of this study was to investigate the association between gram negative enteric rods and Porphyromonas gingivalis and changes in clinical parameters in chronic periodontitis subjects. Occurrence of Gram negative enteric rods, Porph...