Watercress (Nasturtium officinale) colour changes due to blanching by heat and a combined treatment of heat/ultrasound (thermosonication) were studied in the temperature range of 82.5 to 92.5 °C. The application of thermosonication was intended to enable less severe blanching treatments and, therefore, improve the quality of the blanched product. The thermosonication blanching processes promote...

ion with 5 states. However, for the Buchi structure K4 of Figure 2(b),fabs(K4) and K4 are not fairly bisimilar.It therefore remains an open problem to construct, in general, a minimalstructure which is fairly bisimilar to K (where minimality is measured in thenumber of states).References[ASB94] A. Aziz, V. Singhal, F. Balarin, R.K. Brayton, and A.L. Sangiovanni-...

Background: Tyrosine kinase 2 (TYK2) is an intracellular that mediates signaling by key cytokines involved in psoriatic arthritis (PsA) and plaque psoriasis (PsO) pathogenesis. Deucravacitinib a novel oral agent selectively inhibits TYK2 via allosteric mechanism binding to the nonconserved regulatory domain of kinase. A previous Phase trial PsO had demonstrated deucravacitinib was efficacious w...

how to cite this article: singhal r, pandit s, saini a, singh p, dhawan n. the acrocallosal syndrome in a neonate with further widening of phenotypic expression. iran j child neurol. 2014 spring;8(2):60-64.   the presentation of the typical characteristics of the acrocallosal syndrome (acls) are hypoplasia/agenesis of corpus callosum, moderate to severe mental retardation, characteristic cranio...

Background Tyrosine kinase 2 (TYK2) mediates signaling of Type I interferons, IL-23, and IL-12, key cytokines involved in lupus pathogenesis. Deucravacitinib (DEUC) is an oral, selective, allosteric TYK2 inhibitor with a unique mechanism action, distinct from Janus (JAK) 1/2/3 inhibitors, has shown efficacy psoriasis psoriatic arthritis. Objectives Assess safety DEUC patients active systemic er...

Background: Upadacitinib (UPA), an oral Janus kinase inhibitor, demonstrated significant improvements in signs, symptoms, and structural inhibition as monotherapy (mono) vs methotrexate (MTX) MTX-naïve patients (pts) with rheumatoid arthritis (RA) through 48 weeks (wks). 1 Objectives: To report the efficacy safety of UPA MTX mono up to 156 wks pts RA from ongoing long-term extension (LTE) SELEC...

2*-b-Fluoro-2*,3*-dideoxyadenosine (F-ddA, lodenosine) is a nucleoside analog that was rationally designed as a more chemically and enzymatically stable anti-AIDS drug than its parent compound 2*,3*-dideoxyadenosine or didanosine. Plasma and cerebrospinal fluid (CSF) pharmacokinetics of this compound and its major metabolite, 2*-b-fluoro-2*,3*-dideoxyinosine (F-ddI), were studied in three rhesu...

Dear Editor, Pan et al. (2016) presented evidence that the plant ubiquitin E3 ligase SP1 directs proteasome-mediated regulation of the peroxisomal protein import machinery. This was surprising, as SP1 was originally identified as a chloroplast outer envelope-localized regulator of the chloroplast protein import machinery (Ling et al., 2012; Ling and Jarvis, 2015), and there was nothing in the o...

Supply chain risk management (SCRM) has increasingly become a more favored research area for academicians and practitioners in recent years. SCRM has been considered an important source of competitive advantage and as an effective method of reducing vulnerability in supply chain systems. Supply chain risk and uncertainty and their related potential losses are becoming much larger as the frequen...

Web technology is transforming all businesses into information-based activities and the rate of technological change is so high that emerging electronic commerce is already making fundamental changes in the economic landscape, affecting every aspect of how business is and will be conducted. There is substantial evidence to suggest that e-banking is being embraced by financial institutions in de...